Rabbit Anti-phospho-TOP2A (Ser1106)/FITC Conjugated antibody
|别 名||TOP2A (phospho Ser1106); TOP2A (phospho S1106); Topoisomerase II alpha (phospho S1106); DNA topoisomeraseⅡalpha; DNA topoisomerase 2-alpha; DNA topoisomerase II, alpha isozyme; TOP2; TP2A; TOP2A; DNA topoisomerase II 170 kD; DNA topoisomerase II alpha isozyme; DNA Topoisomerase2; TOP 2A; TopII alpha; Topo II alpha; Topoisomerase DNA II alpha 170kDa; Topoisomerase II alpha 170 kDa; TOP2A_HUMAN; Topo IIα; Topo-IIα.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 细胞生物 免疫学 转录调节因子 激酶和***酸酶|
|交叉反应||Human, Dog, Pig, Sheep, Danio|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||174kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated Synthesised phosphopeptide derived from human TOPO II Alpha around the phosphorylation site of Ser1106|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.
Homodimer. Interacts with COPS5.
Cytoplasm. Nucleus, nucleoplasm. Note=Generally located in the nucleoplasm.
Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation.
Belongs to the type II topoisomerase family.
Contains 1 Toprim domain.
Entrez Gene: 7153 Human
Entrez Gene: 21973 Mouse
Entrez Gene: 360243 Rat
Omim: 126430 Human
SwissProt: P11388 Human
SwissProt: Q01320 Mouse
SwissProt: P41516 Rat
Unigene: 156346 Human
Unigene: 4237 Mouse
Unigene: 90996 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
这个基因编码一个DNA拓扑异构酶，一种控制和改变DNA转录过程中的拓扑状态的酶。这种核酶参与了染色体缩合、染色单体分离和DNA转录和复制过程中产生的扭转应力等过程。它催化了两股双链DNA的瞬时断裂和重新连接，这允许DNA链彼此穿过，从而改变DNA的拓扑结构。这种酶的两种形式存在作为基因复制事件的可能产物。编码这种形式的基因α，定位于第17染色体，β基因定位于3号染色体。编码这种酶的基因作为几种抗癌药物的靶标，这种基因中的各种突变与耐药性的发展有关。这种酶的活性降低也可能在共济失调毛细血管扩张症中发挥作用。[ RefSeq，JUL 2010 ]