FITC标记的磷酸化NF-κB活化激酶抗体
产品名称： FITC标记的磷酸化NF-κB活化激酶抗体
英文名称： Anti-Phospho-TBK1 (Ser172)/FITC
产品编号： HZ-3440R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Phospho-TBK1 (Ser172)/FITC Conjugated antibody
FITC标记的磷酸化NF-κB活化激酶抗体
| 英文名称 | Anti-Phospho-TBK1 (Ser172)/FITC |
| 中文名称 | FITC标记的磷酸化NF-κB活化激酶抗体 |
| 别 名 | NAK (phospho S172); Phospho-TBK1/NAK (Ser172); P-TBK1(Ser172); p-NAK(Ser172); TRAF-associated NF-κB kinase; TANK protein; TANK-binding kinase 1; T2K; NF-kappa-B-activating kinase; Serine/threonine-protein kinase TBK1; I TRAF; ITRAF; TRAF family member associated NF KAPPA B activator; TRAF family member associated NFKB activator; TRAF interacting protein; TRAF interacting protein TANK isoform a; TRAF interacting protein TANK isoform b; TRAF2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 84kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human TBK1 around the phosphorylation site of Ser172 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively. Ubiquitous with higher expression in testis. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. Subunit: Self-associates. Interacts with TIRAP, TANK and TRAF2. Part of a ternary complex consisting of TANK, TRAF2 and TBK1. Subcellular Location: Cytoplasm. Tissue Specificity: Ubiquitous with higher expression in testis. Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. Contains 1 protein kinase domain. Contains 1 ubiquitin-like domain. Database links: Entrez Gene: 29110 Human Entrez Gene: 56480 Mouse Entrez Gene: 299827 Rat Omim: 604834 Human SwissProt: Q9UHD2 Human SwissProt: Q9WUN2 Mouse Unigene: 505874 Human Unigene: 34580 Mouse Unigene: 30683 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. TBK1是NF-κB信号通道中的一种激酶，它是被KRAS-改变的细胞存活所必不可少的。TBK1诱导反凋亡信号，TBK1与NF-κB共同作用于KRAS介导的癌变过程中,可能是一个癌症治疗目标 |
Serine /苏氨酸蛋白参与到转录因子NF-kAPA-B激活的信号级联中，可以作为IKK激酶发挥作用，在TNF-α诱导基因的子集的转录中起着至关重要的作用。还介导RANTES/CCR5和干扰素β/IFNB1的产生。在先天免疫应答中具有重要作用。磷酸化博尔纳病病毒（BDV）P蛋白。磷酸化和激活Irf3和Irf7，并允许它们的核定位。这导致α/β干扰素的产生和细胞抗病毒状态的发展。它似乎也是诱导抗病毒干扰素应答的中心因素。抑制丙型肝炎病毒NS3结合或BDV P蛋白与Irf3的相互作用似乎是抑制丙型肝炎病毒（HCV）感染或博尔纳病病毒感染的固有免疫应答的一种机制。睾丸中普遍存在高表达。属于蛋白激酶超家族。SE/THR蛋白激酶家族。I-κB激酶亚家族。