FITC标记的磷酸化NF-κB活化激酶抗体上海沪震实业有限公司

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产品名称: FITC标记的磷酸化NF-κB活化激酶抗体
英文名称: Anti-Phospho-TBK1 (Ser172)/FITC
抗体货号: HZ-3440R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/9 10:17:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Phospho-TBK1 (Ser172)/FITC Conjugated antibody

FITC标记的***酸化NF-κB活化激酶抗体

 

英文名称 Anti-Phospho-TBK1 (Ser172)/FITC
中文名称 FITC标记的***酸化NF-κB活化激酶抗体
别    名 NAK (phospho S172); Phospho-TBK1/NAK (Ser172); P-TBK1(Ser172); p-NAK(Ser172); TRAF-associated NF-κB kinase; TANK protein; TANK-binding kinase 1; T2K; NF-kappa-B-activating kinase; Serine/threonine-protein kinase TBK1; I TRAF; ITRAF; TRAF family member associated NF KAPPA B activator; TRAF family member associated NFKB activator; TRAF interacting protein; TRAF interacting protein TANK isoform a; TRAF interacting protein TANK isoform b; TRAF2.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 肿瘤  免疫学  信号转导  细胞凋亡  转录调节因子  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 84kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human TBK1 around the phosphorylation site of Ser172
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively. Ubiquitous with higher expression in testis. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.

Subunit:
Self-associates. Interacts with TIRAP, TANK and TRAF2. Part of a ternary complex consisting of TANK, TRAF2 and TBK1.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Ubiquitous with higher expression in testis.

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. 
Contains 1 protein kinase domain. 
Contains 1 ubiquitin-like domain.

Database links:

Entrez Gene: 29110 Human

Entrez Gene: 56480 Mouse

Entrez Gene: 299827 Rat

Omim: 604834 Human

SwissProt: Q9UHD2 Human

SwissProt: Q9WUN2 Mouse

Unigene: 505874 Human

Unigene: 34580 Mouse

Unigene: 30683 Rat

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

TBK1是NF-κB信号通道中的一种激酶,它是被KRAS-改变的细胞存活所必不可少的。TBK1诱导反凋亡信号,TBK1与NF-κB共同作用于KRAS介导的癌变过程中,可能是一个癌症治疗目标
   

Serine /苏氨酸蛋白参与到转录因子NF-kAPA-B激活的信号级联中,可以作为IKK激酶发挥作用,在TNF-α诱导基因的子集的转录中起着至关重要的作用。还介导RANTES/CCR5和干扰素β/IFNB1的产生。在先天免疫应答中具有重要作用。***酸化博尔纳病病毒(BDV)P蛋白。***酸化和激活Irf3和Irf7,并允许它们的核定位。这导致α/β干扰素的产生和细胞抗病毒状态的发展。它似乎也是诱导抗病毒干扰素应答的中心因素。抑制丙型肝炎病毒NS3结合或BDV P蛋白与Irf3的相互作用似乎是抑制丙型肝炎病毒(HCV)感染或博尔纳病病毒感染的固有免疫应答的一种机制。睾丸中普遍存在高表达。属于蛋白激酶超家族。SE/THR蛋白激酶家族。I-κB激酶亚家族。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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