FITC标记的磷酸化A-Raf抗体
产品名称： FITC标记的磷酸化A-Raf抗体
英文名称： Anti-Phospho-A Raf (Tyr301 + Tyr302)/FITC
产品编号： HZ-3421R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Phospho-A Raf (Tyr301 + Tyr302)/FITC Conjugated antibody
FITC标记的磷酸化A-Raf抗体
| 英文名称Anti-Phospho-A Raf (Tyr301 + Tyr302)/FITC中文名称FITC标记的磷酸化A-Raf抗体别 名A RAF (phospho Y301 + Y302); p-A RAF (phospho Y301 + Y302); A raf 1; A Raf proto oncogene serine/threonine protein kinase; ARAF 1; ARAF; ARaf proto oncogene serine/threonine protein kinase; ARAF1; Oncogene Araf1; Oncogene PKS2; PKS 2; PKS; PKS2; Proto oncogene Pks; RAFA 1; RAFA1; Ras binding protein DA Raf; v raf murine sarcoma 3611 viral oncogene homolog; v raf murine sarcoma 3611 viral oncogene homolog 1; v raf oncogene homolog 1 (murine sarcoma 3611 virus); ARAF_HUMAN. 规格价格100ul/2980元 购买 大包装/询价说 明 书100ul 产品类型磷酸化抗体 研究领域肿瘤 免疫学 信号转导 转录调节因子 表观遗传学 抗体来源Rabbit克隆类型Polyclonal交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 产品应用IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.分 子 量67kDa性 状Lyophilized or Liquid浓 度1mg/ml免 疫 原KLH conjugated Synthesised phosphopeptide derived from human A Raf around the phosphorylation site of Tyr301/302 [G(p-Y)(p-Y)WE]亚 型IgG纯化方法affinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.产品介绍background: The RAF family of signaling proteins has three isoforms: A RAF, RAF 1 and B RAF. These proteins are instrumental in forwarding the stimulus generated by mitogens from monomeric G proteins to the MAP kinase pathway. RAF 1 is known to be downstream of Ras and binds to it by an N terminal noncatalytic domain. This domain is conserved in A RAF and B RAF. 14-3-3 is also known to be an activator of RAFs. Activated RAF directly phosphorylates and activates MEK. A RAF is expressed at a very high concentration in urogenital and kidney tissues. Function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Subunit: Interacts with TH1L/NELFD. Tissue Specificity: Predominantly in urogenital tissues. Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 protein kinase domain. Contains 1 RBD (Ras-binding) domain. Database links: Entrez Gene: 369 Human Entrez Gene: 397601 Pig Entrez Gene: 64363 Rat Entrez Gene: 403063 Zebrafish Omim: 311010 Human SwissProt: P10398 Human SwissProt: O19004 Pig SwissProt: P14056 Rat Unigen: 446641 Human Unigene: 1714 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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Rac家族的信号蛋白有三种亚型：RAF、RAF 1和B RAF。这些蛋白有助于从单体G蛋白向MAP激酶途径传递由有丝分裂原产生的刺激。RAF 1已知是RAS的下游，并通过N末端非催化结构域与它结合。该域在RAF和B RAF中是保守的。14-3-3也被称为RAF的活化剂。活化的RAF直接磷酸化并激活MEK。RAF在泌尿生殖道和肾组织中表达非常高。