FITC标记的细胞膜铁转运蛋白FP1抗体
产品名称： FITC标记的细胞膜铁转运蛋白FP1抗体
英文名称： Anti-SLC40A1/FITC
产品编号： HZ-3579R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-SLC40A1/FITC Conjugated antibody
FITC标记的细胞膜铁转运蛋白FP1抗体
| 英文名称 | Anti-SLC40A1/FITC |
| 中文名称 | FITC标记的细胞膜铁转运蛋白FP1抗体 |
| 别 名 | Ferroportin 1; Ferroportin-1; FPN1; HFE4; IREG1; Iron regulated transporter 1; Iron-regulated transporter 1; MTP1; S40A1_HUMAN; SLC40A1; Solute carrier family 40 member 1; MST0a79; MSTP079; MTP1; SLC11A3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 63kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SLC40A1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: SLC40A1 may be involved in iron export from duodenal epithelial cells and also in transfer of iron between maternal and fetal circulation. It mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4, an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin. Function: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Subcellular Location: Cell membrane; Multi-pass membrane protein. Note=Localized to the basolateral membrane of polarized epithelial cells. Tissue Specificity: Expressed in placenta, intestine, muscle and spleen. DISEASE: Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4) [MIM:606069]. HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Similarity: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. Database links: Entrez Gene: 30061 Human Entrez Gene: 53945 Mouse Entrez Gene: 170840 Rat Omim: 604653 Human SwissProt: Q9NP59 Human SwissProt: Q9JHI9 Mouse SwissProt: Q923U9 Rat Unigene: 643005 Human Unigene: 28756 Mouse Unigene: 15324 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
SLC40A1可能参与了十二指肠上皮细胞的铁输出，也参与了母体和胎儿循环之间的铁传递。它在铁氧化酶（Heaestin和/或铜蓝蛋白）的存在下介导铁流出。SLC40A1中的缺陷是血色素沉着症4型的原因，常染色体显性铁负荷障碍以网状内皮细胞早期铁积聚为特征，血清铁蛋白显著增加。