FITC标记的去整合素样金属蛋白酶10抗体
产品名称： FITC标记的去整合素样金属蛋白酶10抗体
英文名称： Anti-ADAM10/MADM/FITC
产品编号： HZ-3574R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-ADAM10/MADM/FITC Conjugated antibody
FITC标记的去整合素样金属蛋白酶10抗体
| 英文名称 | Anti-ADAM10/MADM/FITC |
| 中文名称 | FITC标记的去整合素样金属蛋白酶10抗体 |
| 别 名 | A disintegrin and metalloprotease domain 10; A Disintegrin And Metalloproteinase Domain 10; ADAM 10; ADAM metallopeptidase domain 10; CD 156c; CD156c; CD156c antigen; CDw156 antibody HsT 18717; HsT18717; kuz; kuzbanian; Kuzbanian protein homolog; MADM; Mammalian disintegrin metalloprotease; ADA10_HUMAN; RAK; kuz; AD10. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 神经生物学 细胞表面分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 84kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ADAM10 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: ADAM10 is a member of the ADAM (a disintegrin and metalloprotease like domain) family. It cleaves the membrane-bound precursor of TNF-alpha at 76-Ala-|-Val-77 to its mature soluble form and is responsible for the proteolytic release of several cell-surface proteins, including heparin binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). It contributes to the normal cleavage of the cellular prion protein and is involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicules, suggesting a vesicle-based protease activity. Subunit: Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP5 or another immunophilin, or the immunophilin homolog PPP5C. Directly interacts with UNC45A. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates (By similarity). Binds to DNA as a homodimer, and as a heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with NCOA1, NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1 (By similarity). Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1, PELP1 and TGFB1I1. Subcellular Location: Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding. Isoform Beta: Nucleus. Note=Localized largely in the nucleus. Tissue Specificity: Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. Similarity: Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. Database links: Entrez Gene: 102 Human Entrez Gene: 11487 Mouse Omim: 602192 Human SwissProt: O14672 Human SwissProt: O35598 Mouse Unigene: 172028 Human Unigene: 578508 Human Unigene: 3037 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
ADAM10是亚当（解体蛋白和金属蛋白酶样结构域）家族的成员。它将TNF-α的膜结合前体在76的ALA-β-VAL-77中裂解为其成熟的可溶性形式，并负责多种细胞表面蛋白的蛋白水解释放，包括肝素结合的表皮生长因子、EphRIN A2和组成型和调节的α分泌酶CL。淀粉样前体蛋白（APP）的吞噬。它有助于细胞朊病毒蛋白的正常切割，并且参与粘附分子L1在细胞表面和释放的膜泡中的裂解，提示囊泡蛋白酶活性。