FITC标记的磷酸化血清应答因子抗体
产品名称: FITC标记的磷酸化血清应答因子抗体
英文名称: Anti-Phospho-SRF (Ser103)/FITC
产品编号: HZ-3409R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: IF=1:50-200
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Rabbit Anti-Phospho-SRF (Ser103)/FITC Conjugated antibody
FITC标记的磷酸化血清应答因子抗体
英文名称 | Anti-Phospho-SRF (Ser103)/FITC |
中文名称 | FITC标记的磷酸化血清应答因子抗体 |
别 名 | Serum Response Factor SRF (phospho S103); SRF (phospho Ser103); P-SRF (Ser103); ELK3 (phospho S103); p-ELK3 (phospho S103); c fos serum response element binding factor; Serum Response Factor SRF; c fos serum response element binding transcription factor; ELK3; ERP; MCM 1; MCM-1; MCM1; OTTHUMP00000039820; SAP2; Serum response factor; SRF; SRF serum response factor c fos serum response element binding transcription factor; SRF_HUMAN. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
产品类型 | 磷酸化抗体 |
研究领域 | 肿瘤 免疫学 信号转导 转录调节因子 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, |
产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 56kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human SRF around the phosphorylation site of Ser103 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). [provided by RefSeq, Jul 2008]. Function: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation. Subunit: Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with ARID2 and SRFBP1. Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1. Forms a nuclear ternary complex with MKL1 and SCAI. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated by PRKDC. Similarity: Contains 1 MADS-box domain. Database links: Entrez Gene: 6722 Human Entrez Gene: 20807 Mouse Omim: 600589 Human SwissProt: P11831 Human SwissProt: Q9JM73 Mouse Unigene: 520140 Human Unigene: 45044 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 转录调节因子(Transcriptin Regulators) 血清应答因子(SRF)是一种转录因子蛋白,可以结合启动子DNA序列中的血清应答元件(SRE),调节一系列基因的表达,包括即刻早期基因的表达,如c-fos、fosB、junB、egr-1、egr-2,以及神经元基因nurr1、肌肉基因如肌动蛋白、肌球蛋白基因等. |
该基因编码一个无处不在的核蛋白,刺激细胞增殖和分化。它是MADS(McM1,AgOndox,Survivin,SRF)盒转录因子超家族成员。该蛋白与靶基因启动子区的血清应答元件(SRE)结合。这种蛋白质调节许多即刻早期基因的活性,例如c-fos,从而参与细胞周期调控、细胞凋亡、细胞生长和细胞分化。该基因是许多途径的下游靶点,例如,通过三元复合因子(TCFs)发挥作用的丝裂原活化蛋白激酶途径(MAPK)。[ RefSeq,JUL 2008 ]提供。