FITC标记的磷酸化蛋白酪氨酸磷酸酶2抗体
产品名称： FITC标记的磷酸化蛋白酪氨酸磷酸酶2抗体
英文名称： Anti-Phospho-SHP2 (Tyr542)/FITC
产品编号： HZ-3403R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Phospho-SHP2 (Tyr542)/FITC Conjugated antibody
FITC标记的磷酸化蛋白酪氨酸磷酸酶2抗体
| 英文名称 | Anti-Phospho-SHP2 (Tyr542)/FITC |
| 中文名称 | FITC标记的磷酸化蛋白酪氨酸磷酸酶2抗体 |
| 别 名 | SHP-2(Phospho-Tyr542); SHP2 (Phospho-Tyr542); SHP2 (Phospho-Y542); p-SHP2 (Tyr542); p-SHP2 (Y542); PTPN11; BPTP 3; BPTP3; CFC; MGC14433; Noonan syndrome 1; Noonan syndrome 1 protein tyrosine phosphatase 2C; NS 1; NS1; Protein tyrosine phosphatase 2C; Protein Tyrosine Phosphatase Non receptor Type 11; PTP 1D; PTP 2C; PTP1D; PTP2C; PTPN 11; PTPN11; SAP2; SH PTP2; SH PTP3; SH2 domain containing protein tyrosine phosphatase 2; SHIP2; SHP 2; SHP-2; SHPTP 2; SHPTP2; SHPTP3; SIT protein precursor; Syp; Tyrosine protein phosphatase non receptor type 11; Src homology 2 (SH2) domain containing phosphotyrosinephosphatase 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 免疫学 信号转导 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 66kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human PTPN11 around the phosphorylation site of Tyr542 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non transmembrane PTP, designated SHPTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N terminal to the PTP domain. A second and much more widely expressed PTP with SH2 domains, SHPTP2 (also designated PTP1D and Syp), has been identified. SHP2 is a protein tyrosine phosphatase that is widely expressed and plays a regulatory role in various cell signaling events that are important for many cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Subunit: Interacts with phosphorylated LIME1 and BCAR3. Interacts with SHB and INPP5D/SHIP1 (By similarity). Interacts with MILR1 (tyrosine-phosphorylated). Interacts with FLT1 (tyrosine-phosphorylated), FLT3 (tyrosine-phosphorylated), FLT4 (tyrosine-phosphorylated), KIT and GRB2. Interacts with PDGFRA (tyrosine phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts with PTPNS1 and CD84. Interacts with phosphorylated SIT1 and MPZL1. Interacts with FCRL3, FCRL4, FCRL6 and ANKHD1. Interacts with KIR2DL1; the interaction is enhanced by ARRB2. Interacts with GAB2. Interacts with TERT; the interaction retains TERT in the nucleus. Interacts with PECAM1 and FER. Interacts with EPHA2 (activated); participates in PTK2/FAK1 dephosphorylation in EPHA2 downstream signaling. Interacts with ROS1; mediates PTPN11 phosphorylation. Interacts with PDGFRB (tyrosine phosphorylated); this interaction increases the PTPN11 phosphatase activity. Subcellular Location: Cytoplasm. Tissue Specificity: Widely expressed, with highest levels in heart, brain, and skeletal muscle. Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. Contains 2 SH2 domains. Contains 1 tyrosine-protein phosphatase domain. Database links: Entrez Gene: 5781 Human Entrez Gene: 19247 Mouse Entrez Gene: 25622 Rat Omim: 176876 Human SwissProt: Q06124 Human SwissProt: P35235 Mouse SwissProt: P41499 Rat Unigene: 506852 Human Unigene: 474046 Mouse Unigene: 8681 Mouse Unigene: 98209 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. SHP2(SH-PTP2)参与多种细胞内信号传导 如MAP kinase、 PI3k等途径，SHP2也是许多其他原癌基因信号通路的重要组成部分，在细胞的增殖及分化等过程扮演重要的角色 |
酪氨酸激酶和蛋白酪氨酸磷酸酶（PTPS）的相反作用调节了细胞中酪氨酸酶磷酸化的稳态。几个组已经独立地鉴定出一种非跨膜的PTP，被指定为SHPTP1（也称为PTP1C、HCP和SHP），其主要在造血细胞中表达，并且其特征在于存在两个SHP结构域N末端至PTP结构域。已经鉴定出第二个和更广泛表达的具有SH2结构域的PTP，SHPTP2（也被命名为PTP1D和SYP）。Spp2是一种蛋白酪氨酸磷酸酶，广泛表达于多种细胞信号转导过程中，对许多细胞功能具有重要的调控作用，如促分裂原激活、代谢调控、转录调控和细胞迁移等。