FITC标记的磷酸化蛋白酪氨酸磷酸酶2抗体上海沪震实业有限公司

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产品名称: FITC标记的磷酸化蛋白酪氨酸磷酸酶2抗体
英文名称: Anti-Phospho-SHP2 (Tyr542)/FITC
抗体货号: HZ-3403R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/9 11:24:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-Phospho-SHP2 (Tyr542)/FITC Conjugated antibody

FITC标记的***酸化蛋白酪氨酸***酸酶2抗体

 

英文名称 Anti-Phospho-SHP2 (Tyr542)/FITC
中文名称 FITC标记的***酸化蛋白酪氨酸***酸酶2抗体
别    名 SHP-2(Phospho-Tyr542); SHP2 (Phospho-Tyr542); SHP2 (Phospho-Y542); p-SHP2 (Tyr542); p-SHP2 (Y542); PTPN11; BPTP 3; BPTP3; CFC; MGC14433; Noonan syndrome 1; Noonan syndrome 1 protein tyrosine phosphatase 2C; NS 1; NS1; Protein tyrosine phosphatase 2C; Protein Tyrosine Phosphatase Non receptor Type 11; PTP 1D; PTP 2C; PTP1D; PTP2C; PTPN 11; PTPN11; SAP2; SH PTP2; SH PTP3; SH2 domain containing protein tyrosine phosphatase 2; SHIP2; SHP 2; SHP-2; SHPTP 2; SHPTP2; SHPTP3; SIT protein precursor; Syp; Tyrosine protein phosphatase non receptor type 11; Src homology 2 (SH2) domain containing phosphotyrosinephosphatase 2.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 肿瘤  免疫学  信号转导  转录调节因子  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 66kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human PTPN11 around the phosphorylation site of Tyr542
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non transmembrane PTP, designated SHPTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N terminal to the PTP domain. A second and much more widely expressed PTP with SH2 domains, SHPTP2 (also designated PTP1D and Syp), has been identified. SHP2 is a protein tyrosine phosphatase that is widely expressed and plays a regulatory role in various cell signaling events that are important for many cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.

Subunit:
Interacts with phosphorylated LIME1 and BCAR3. Interacts with SHB and INPP5D/SHIP1 (By similarity). Interacts with MILR1 (tyrosine-phosphorylated). Interacts with FLT1 (tyrosine-phosphorylated), FLT3 (tyrosine-phosphorylated), FLT4 (tyrosine-phosphorylated), KIT and GRB2. Interacts with PDGFRA (tyrosine phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts with PTPNS1 and CD84. Interacts with phosphorylated SIT1 and MPZL1. Interacts with FCRL3, FCRL4, FCRL6 and ANKHD1. Interacts with KIR2DL1; the interaction is enhanced by ARRB2. Interacts with GAB2. Interacts with TERT; the interaction retains TERT in the nucleus. Interacts with PECAM1 and FER. Interacts with EPHA2 (activated); participates in PTK2/FAK1 dephosphorylation in EPHA2 downstream signaling. Interacts with ROS1; mediates PTPN11 phosphorylation. Interacts with PDGFRB (tyrosine phosphorylated); this interaction increases the PTPN11 phosphatase activity.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Widely expressed, with highest levels in heart, brain, and skeletal muscle.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Contains 2 SH2 domains.
Contains 1 tyrosine-protein phosphatase domain.

Database links:

Entrez Gene: 5781 Human

Entrez Gene: 19247 Mouse

Entrez Gene: 25622 Rat

Omim: 176876 Human

SwissProt: Q06124 Human

SwissProt: P35235 Mouse

SwissProt: P41499 Rat

Unigene: 506852 Human

Unigene: 474046 Mouse

Unigene: 8681 Mouse

Unigene: 98209 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

SHP2(SH-PTP2)参与多种细胞内信号传导 如MAP kinase、 PI3k等途径,SHP2也是许多其他原癌基因信号通路的重要组成部分,在细胞的增殖及分化等过程扮演重要的角色
   

酪氨酸激酶和蛋白酪氨酸***酸酶(PTPS)的相反作用调节了细胞中酪氨酸酶***酸化的稳态。几个组已经独立地鉴定出一种非跨膜的PTP,被指定为SHPTP1(也称为PTP1C、HCP和SHP),其主要在造血细胞中表达,并且其特征在于存在两个SHP结构域N末端至PTP结构域。已经鉴定出第二个和更广泛表达的具有SH2结构域的PTP,SHPTP2(也被命名为PTP1D和SYP)。Spp2是一种蛋白酪氨酸***酸酶,广泛表达于多种细胞信号转导过程中,对许多细胞功能具有重要的调控作用,如促分裂原激活、代谢调控、转录调控和细胞迁移等。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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