Rabbit Anti-RPS6/FITC Conjugated antibody
|别 名||40S ribosomal protein S6; Air8; DS6; Hemocytes enlarged; Hen; L(1)AIR8; Lethal (1) haemocytes enlarged; Lethal aberrant immune response 8; Lethal(1)abberant immune response; Phosphoprotein NP33; Pp30; Ribosomal protein S6; RP S6; RPS 6; RpS6; RS6; RS6_HUMAN; S6; S6 Ribosomal Protein.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 细胞生物 免疫学|
|交叉反应||Human, Mouse, Rat, Pig, Cow, Rabbit,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||29kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human RPS6(176-237aa)|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphrylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the preinitiation complex.
Belongs to the ribosomal protein S6e family.
Entrez Gene: 6194 Human
Entrez Gene: 20104 Mouse
Entrez Gene: 667739 Mouse
Entrez Gene: 29304 Rat
Omim: 180460 Human
SwissProt: P62753 Human
SwissProt: P62754 Mouse
SwissProt: P62755 Rat
Unigene: 408073 Human
Unigene: 379007 Mouse
Unigene: 425090 Mouse
Unigene: 34341 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
Ribosomes，催化蛋白质合成的细胞器，由一个小的40S亚基和一个大的60S亚基组成。这些亚基由4种RNA和大约80种结构上不同的蛋白质组成。该基因编码细胞质核糖体蛋白，其是40S亚基的一个组成部分。该蛋白属于核糖体蛋白的S6E家族。它是核糖体中蛋白激酶的主要底物，具有不同的蛋白激酶***酸化的五个C-末端丝氨酸残基的子集。***酸化是由广泛的刺激，包括生长因子、促肿瘤剂和有丝分裂原引起的。脱***作用发生在生长停滞期。通过选择性翻译特定的mRNA，该蛋白可能有助于细胞生长和增殖的控制。对于编码核糖体蛋白的基因来说是典型的，这种基因的多个假基因通过基因组分散。[ RefSeq，JUL 2008 ]