FITC标记的磷酸化细胞核受体Rev-Erbα抗体-抗体-抗体-生物在线
FITC标记的磷酸化细胞核受体Rev-Erbα抗体

FITC标记的磷酸化细胞核受体Rev-Erbα抗体

商家询价

产品名称: FITC标记的磷酸化细胞核受体Rev-Erbα抗体

英文名称: Anti-Phospho-NR1D1(Ser55 + Ser59)/FITC

产品编号: HZ-

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: IF=1:50-200

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 Rabbit Anti-Phospho-NR1D1(Ser55 + Ser59)/FITC Conjugated antibody

FITC标记的磷酸化细胞核受体Rev-Erbα抗体

 

英文名称 Anti-Phospho-NR1D1(Ser55 + Ser59)/FITC
中文名称 FITC标记的磷酸化细胞核受体Rev-Erbα抗体
别    名 EAR-1; EAR1; ERBA-RELATED 1; hRev; Nr1d1; NR1D1_HUMAN; Nuclear Receptor Rev-ErbA Alpha; Nuclear receptor subfamily 1 group D member 1; Orphan nuclear receptor NR1D1; Rev erbAalpha; Rev erbalpha; Rev-erbA-alpha; Rev-ErbAalpha; REV-ERBalpha; THRA1; THRAL; Thyroid hormone receptor alpha-like; Thyroid hormone receptor, alpha like; V-erbA related protein EAR-1; V-erbA-related protein 1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 磷酸化抗体 
研究领域 细胞生物  免疫学  染色质和核信号  神经生物学  信号转导  生长因子和  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Sheep, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 67kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human REV-ERB alpha around the phosphorylation site of Ser55/59
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
NR1D1, a NR1 Thyroid Hormone-Like Receptor, is encoded by the same genomic locus as, but transcribed from the opposite strand of, Thyroid Hormone Receptor Alpha (TR Alpha). NR1D1 is a target of Nuclear Receptor ROR Alpha and a transcription regulator that has been shown to affect myocyte differentiation, adipogenesis, and lipoprotein metabolism. Mice lacking NR1D1 show abnormal postnatal cerebellar development. NR1D1 expression has been documented in human skeletal muscle and a variety of mouse and rat tissues. ESTs have been isolated from human tissue libraries, including cancerous adrenal, blood, brain, breast, colon, duodenum, fetus, head/neck, kidney, lung, skeletal muscle, skin, synovium, uterus, normal brain, breast, colon, eye, heart, pancreas, pituitary, prostate, skeletal muscle, skin, testis and thyroid.

Function:
Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription. Possible receptor for triiodothyronine. 

Subunit:
Interacts with C1D and NR2E3. Interacts with SP1. 

Subcellular Location:
Nucleus (Potential). 

Tissue Specificity:
Expressed in all tissues and cell lines examined. Expressed at high levels in some squamous carcinoma cell lines.

Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

Database links:

Entrez Gene: 768225 Cow

Entrez Gene: 9572 Human

Entrez Gene: 217166 Mouse

Entrez Gene: 252917 Rat

Omim: 602408 Human

SwissProt: Q08E02 Cow

SwissProt: P20393 Human

SwissProt: Q3UV55 Mouse

SwissProt: Q63503 Rat

Unigene: 592130 Human

Unigene: 724 Human

Unigene: 390397 Mouse

Unigene: 29848 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

1.细胞核受体Rev-Erbα是生物钟系统的重要组成部分,不仅是生物钟基因而且是生物钟调节基因,在维持生物节律准确性中发挥着重要作用;
2.Rev-Erbα调节糖代谢、脂质代谢、脂肪形成、纤溶蛋白降解、血管炎症并与其他能量平衡相关核受体相互作用
   

NR1D1,NR1甲状腺样受体,由相同的基因位点编码,但从甲状腺受体α(TRα)的相反链转录。NR1D1是核受体RoRα和转录调节因子的靶标,已被证明影响心肌细胞分化、脂肪生成和脂蛋白代谢。缺乏NR1D1的小鼠出生后小脑发育异常。NR1D1表达已被记录在人类骨骼肌和各种小鼠和大鼠组织中。ESTs已从人的组织库中分离出来,包括癌性肾上腺、血液、脑、乳腺、结肠、十二指肠、胎儿、头颈部、肾、肺、骨骼肌、皮肤、滑膜、子宫、正常脑、乳腺、结肠、眼、心脏、胰腺、垂体、前列腺、骨骼肌、皮肤、睾丸和甲状腺。