FITC标记的磷酸化细胞核受体Rev-Erbα抗体
产品名称: FITC标记的磷酸化细胞核受体Rev-Erbα抗体
英文名称: Anti-Phospho-NR1D1(Ser55 + Ser59)/FITC
产品编号: HZ-
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: IF=1:50-200
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-Phospho-NR1D1(Ser55 + Ser59)/FITC Conjugated antibody
FITC标记的磷酸化细胞核受体Rev-Erbα抗体
英文名称 | Anti-Phospho-NR1D1(Ser55 + Ser59)/FITC |
中文名称 | FITC标记的磷酸化细胞核受体Rev-Erbα抗体 |
别 名 | EAR-1; EAR1; ERBA-RELATED 1; hRev; Nr1d1; NR1D1_HUMAN; Nuclear Receptor Rev-ErbA Alpha; Nuclear receptor subfamily 1 group D member 1; Orphan nuclear receptor NR1D1; Rev erbAalpha; Rev erbalpha; Rev-erbA-alpha; Rev-ErbAalpha; REV-ERBalpha; THRA1; THRAL; Thyroid hormone receptor alpha-like; Thyroid hormone receptor, alpha like; V-erbA related protein EAR-1; V-erbA-related protein 1. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
产品类型 | 磷酸化抗体 |
研究领域 | 细胞生物 免疫学 染色质和核信号 神经生物学 信号转导 生长因子和 表观遗传学 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Cow, Sheep, |
产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 67kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human REV-ERB alpha around the phosphorylation site of Ser55/59 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: NR1D1, a NR1 Thyroid Hormone-Like Receptor, is encoded by the same genomic locus as, but transcribed from the opposite strand of, Thyroid Hormone Receptor Alpha (TR Alpha). NR1D1 is a target of Nuclear Receptor ROR Alpha and a transcription regulator that has been shown to affect myocyte differentiation, adipogenesis, and lipoprotein metabolism. Mice lacking NR1D1 show abnormal postnatal cerebellar development. NR1D1 expression has been documented in human skeletal muscle and a variety of mouse and rat tissues. ESTs have been isolated from human tissue libraries, including cancerous adrenal, blood, brain, breast, colon, duodenum, fetus, head/neck, kidney, lung, skeletal muscle, skin, synovium, uterus, normal brain, breast, colon, eye, heart, pancreas, pituitary, prostate, skeletal muscle, skin, testis and thyroid. Function: Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription. Possible receptor for triiodothyronine. Subunit: Interacts with C1D and NR2E3. Interacts with SP1. Subcellular Location: Nucleus (Potential). Tissue Specificity: Expressed in all tissues and cell lines examined. Expressed at high levels in some squamous carcinoma cell lines. Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. Database links: Entrez Gene: 768225 Cow Entrez Gene: 9572 Human Entrez Gene: 217166 Mouse Entrez Gene: 252917 Rat Omim: 602408 Human SwissProt: Q08E02 Cow SwissProt: P20393 Human SwissProt: Q3UV55 Mouse SwissProt: Q63503 Rat Unigene: 592130 Human Unigene: 724 Human Unigene: 390397 Mouse Unigene: 29848 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 1.细胞核受体Rev-Erbα是生物钟系统的重要组成部分,不仅是生物钟基因而且是生物钟调节基因,在维持生物节律准确性中发挥着重要作用; 2.Rev-Erbα调节糖代谢、脂质代谢、脂肪形成、纤溶蛋白降解、血管炎症并与其他能量平衡相关核受体相互作用 |
NR1D1,NR1甲状腺样受体,由相同的基因位点编码,但从甲状腺受体α(TRα)的相反链转录。NR1D1是核受体RoRα和转录调节因子的靶标,已被证明影响心肌细胞分化、脂肪生成和脂蛋白代谢。缺乏NR1D1的小鼠出生后小脑发育异常。NR1D1表达已被记录在人类骨骼肌和各种小鼠和大鼠组织中。ESTs已从人的组织库中分离出来,包括癌性肾上腺、血液、脑、乳腺、结肠、十二指肠、胎儿、头颈部、肾、肺、骨骼肌、皮肤、滑膜、子宫、正常脑、乳腺、结肠、眼、心脏、胰腺、垂体、前列腺、骨骼肌、皮肤、睾丸和甲状腺。