FITC标记的Ras特异性鸟嘌呤核苷酸释放因子1
产品名称： FITC标记的Ras特异性鸟嘌呤核苷酸释放因子1
英文名称： Anti-RASGRF1/FITC
产品编号： HZ-3560R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-RASGRF1/FITC Conjugated antibody
FITC标记的Ras特异性鸟嘌呤核苷酸释放因子1
| 英文名称 | Anti-RASGRF1/FITC |
| 中文名称 | FITC标记的Ras特异性鸟嘌呤核苷酸释放因子1 |
| 别 名 | CDC25; CDC25L; GNRP; GRF1; GRF55; Guanine nucleotide exchange factor; Guanine nucleotide releasing factor 55 kD; Guanine nucleotide releasing protein; Guanine nucleotide-releasing protein; H GRF55; HGRF55; PP13187; Ras protein specific guanine nucleotide releasing factor 1; Ras specific guanine nucleotide releasing factor; Ras specific guanine nucleotide releasing factor CDC25 homolog; Ras specific nucleotide exchange factor CDC25; Ras-GRF1; Ras-specific guanine nucleotide-releasing factor 1; Ras-specific nucleotide exchange factor CDC25; RASGRF1; RGRF1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 信号转导 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Guinea Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 145kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RASGRF1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009] Function: Promotes the exchange of Ras-bound GDP by GTP. Subunit: Homooligomer and heterooligomer with RASGRF2. Interacts with USP8, thereby regulating its stability. Post-translational modifications: Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome. Ubiquitinated and degraded following phosphorylation by PLK2 By similarity). Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC seems not to have an effect on stimulation activity. Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 IQ domain. Contains 1 N-terminal Ras-GEF domain. Contains 2 PH domains. Contains 1 Ras-GEF domain. Database links: Entrez Gene: 5923 Human Entrez Gene: 192213 Rat Omim: 606600 Human SwissProt: Q13972 Human SwissProt: P28818 Rat Unigene: 459035 Human Unigene: 135776 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
由该基因编码的蛋白质是类似于酿酒酵母CDC25基因产物的鸟嘌呤核苷酸交换因子（GEF）。功能分析表明，这种蛋白质刺激从Ras蛋白的GDP的解离。小鼠相似基因的研究表明，该蛋白在脑内的RAS GEF活性可被Ca2+内流、毒蕈碱受体和G蛋白β-γ亚单位激活。小鼠研究还表明，由该蛋白介导的RAS GEF信号通路可能对长期记忆很重要。另外，报道了编码不同亚型的剪接转录变体。〔RefSeq，2009〕