FITC标记的磷酸化核糖体蛋白S6激酶家族RSK3抗体上海沪震实业有限公司

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产品名称: FITC标记的磷酸化核糖体蛋白S6激酶家族RSK3抗体
英文名称: Anti-Phospho-RSK3 (Thr356 + Ser360)/FITC
抗体货号: HZ-3366R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/9 13:35:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Phospho-RSK3 (Thr356 + Ser360)/FITC Conjugated antibody

FITC标记的***酸化核糖体蛋白S6激酶家族RSK3抗体

 

英文名称 Anti-Phospho-RSK3 (Thr356 + Ser360)/FITC
中文名称 FITC标记的***酸化核糖体蛋白S6激酶家族RSK3抗体
别    名 RSK3 (Phospho Thr356 + Ser360); RSK3 (Phospho T356 + S360); 90 kDa ribosomal protein S6 kinase 2; HU 2; KS6A2_HUMAN; MAP kinase activated protein kinase 1c; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; MAPKAPK1C; p90-RSK 2; p90RSK 2; p90RSK2; pp90RSK 3; pp90RSK3; Ribosomal protein S6 kinase alpha-2; Ribosomal S6 kinase 3; RPS6KA2; RSK 3; RSK-3; S6K alpha 2; S6K alpha; S6K-alpha-2.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 肿瘤  免疫学  信号转导  细胞凋亡  转录调节因子  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 90kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human RSK3 around the phosphorylation site of Thr356/Ser360
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

Function:
Serine/threonine-protein kinase that acts downstream ofERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenicand stress-induced activation of transcription factors, regulatestranslation, and mediates cellular proliferation, survival, anddifferentiation. May function as tumor suppressor in epithelialovarian cancer cells.

Subunit:
Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 inquiescent cells. Transiently dissociates following mitogenicstimulation.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Widely expressed with higher expression inlung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.

Post-translational modifications:
Activated by phosphorylation at Ser-218 by PDPK1.Autophosphorylated on Ser-377, as part of the activation process.May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 andMAPK3/ERK1. 
N-terminal myristoylation results in an activated kinase inthe absence of added growth factors.

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thrprotein kinase family. S6 kinase subfamily. 
Contains 1 AGC-kinase C-terminal domain. 
Contains 2 protein kinase domains.

Database links:

Entrez Gene: 6196 Human

Entrez Gene: 20112 Mouse

Entrez Gene: 117269 Rat

Omim: 601685 Human

SwissProt: Q15349 Human

SwissProt: Q9WUT3 Mouse

Unigene: 655277 Human

Unigene: 268383 Mouse

Unigene: 2356 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

该基因编码丝氨酸/苏氨酸激酶RSK(核糖体S6激酶)家族的成员。该激酶包含2个不相同的激酶催化域,并***酸化各种底物,包括丝裂原活化激酶(MAPK)信号通路的成员。该蛋白的活性与控制细胞生长和分化有关。编码不同的异构体的交替转录剪接变异体已被表征。[ RefSeq,JUL 2008 ]提供。

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