Rabbit Anti-Phospho-RSK3 (Thr356 + Ser360)/FITC Conjugated antibody
|英文名称||Anti-Phospho-RSK3 (Thr356 + Ser360)/FITC|
|别 名||RSK3 (Phospho Thr356 + Ser360); RSK3 (Phospho T356 + S360); 90 kDa ribosomal protein S6 kinase 2; HU 2; KS6A2_HUMAN; MAP kinase activated protein kinase 1c; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; MAPKAPK1C; p90-RSK 2; p90RSK 2; p90RSK2; pp90RSK 3; pp90RSK3; Ribosomal protein S6 kinase alpha-2; Ribosomal S6 kinase 3; RPS6KA2; RSK 3; RSK-3; S6K alpha 2; S6K alpha; S6K-alpha-2.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子 激酶和***酸酶|
|交叉反应||Human, Mouse, Rat,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||90kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated Synthesised phosphopeptide derived from human RSK3 around the phosphorylation site of Thr356/Ser360|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Serine/threonine-protein kinase that acts downstream ofERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenicand stress-induced activation of transcription factors, regulatestranslation, and mediates cellular proliferation, survival, anddifferentiation. May function as tumor suppressor in epithelialovarian cancer cells.
Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 inquiescent cells. Transiently dissociates following mitogenicstimulation.
Widely expressed with higher expression inlung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
Activated by phosphorylation at Ser-218 by PDPK1.Autophosphorylated on Ser-377, as part of the activation process.May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 andMAPK3/ERK1.
N-terminal myristoylation results in an activated kinase inthe absence of added growth factors.
Belongs to the protein kinase superfamily. AGC Ser/Thrprotein kinase family. S6 kinase subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 2 protein kinase domains.
Entrez Gene: 6196 Human
Entrez Gene: 20112 Mouse
Entrez Gene: 117269 Rat
Omim: 601685 Human
SwissProt: Q15349 Human
SwissProt: Q9WUT3 Mouse
Unigene: 655277 Human
Unigene: 268383 Mouse
Unigene: 2356 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
该基因编码丝氨酸/苏氨酸激酶RSK（核糖体S6激酶）家族的成员。该激酶包含2个不相同的激酶催化域，并***酸化各种底物，包括丝裂原活化激酶（MAPK）信号通路的成员。该蛋白的活性与控制细胞生长和分化有关。编码不同的异构体的交替转录剪接变异体已被表征。[ RefSeq，JUL 2008 ]提供。