Rabbit Anti-Phospho-PSD93 (Tyr340)/FITC Conjugated antibody
|别 名||Channel associated protein of synapse 110; Channel associated protein of synapses 110kD; Channel-associated protein of synapse-110; Chapsyn 110; Chapsyn-110; Chapsyn110; discs large homolog 2; Discs, large homolog 2 (Drosophila); Disks large homolog 2; DKFZp781D1854; DKFZp781E0954; Dlg 2; dlg2; DLG2_HUMAN; Dlgh 2; Dlgh2; FLJ37266; Gm1197; MGC131811; Postsynaptic density protein PSD 93; Postsynaptic density protein PSD-93; Postsynaptic density protein PSD93; PSD 93; PSD93.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||细胞生物 免疫学 神经生物学|
|交叉反应||Human, Mouse, Rat, Chicken, Dog, Horse,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||98kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthesised phosphopeptide derived from human PSD93 around the phosphorylation site of Tyr340|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
PSD 93 is believed to participate in the clustering of certain proteins, including N-methyl-D-aspartate (NMDA) receptors and shaker-type potassium channels at the synaptic membrane. There are two principal modes of interaction between PSD 93 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with PSD 93 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD 93 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).
Interacts through its PDZ domains with NETO1. Interacts with NOS1/nNOS through second PDZ domain (By similarity). Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Interacts with FASLG.
Membrane; Lipid-anchor (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Concentrated in soma and postsynaptic density of a subset of neurons (By similarity).
Palmitoylation of isoform 1 is not required for targeting to postsynaptic density (By similarity).
Belongs to the MAGUK family.
Contains 1 guanylate kinase-like domain.
Contains 3 PDZ (DHR) domains.
Contains 1 SH3 domain.
Entrez Gene: 1740 Human
Entrez Gene: 23859 Mouse
Entrez Gene: 64053 Rat
Omim: 603583 Human
SwissProt: Q15700 Human
SwissProt: Q91XM9 Mouse
SwissProt: Q63622 Rat
Unigene: 367656 Human
Unigene: 147213 Mouse
Unigene: 257035 Mouse
Unigene: 202966 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
PSD 93被认为参与了某些蛋白质的聚集，包括N-甲基-D-天门冬氨酸（NMDA）受体和突触膜上的振动器型钾通道。PSD 93与其它蛋白质之间存在两种主要的相互作用模式。NMDA受体和振动器型钾通道均具有由苏氨酸/丝氨酸-X-缬氨酸-COOH（t/SXV）基序组成的C-末端序列同源性。其他神经元蛋白共享这一主题（β1***能受体，一些血清素受体，一些钠通道亚基，和额外的钾通道亚基）可以与PSD 93通过结合其PDZ结构域相互作用。神经型一氧化氮合酶（nNOS）缺乏T/SXV基序，但具有其自身的PDZ结构域，已通过伪同型PDZ-PDZ相互作用与PSD 93在体外相关联。