FITC标记的磷酸化丝/苏氨酸蛋白激酶Plk1抗体上海沪震实业有限公司

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产品名称: FITC标记的磷酸化丝/苏氨酸蛋白激酶Plk1抗体
英文名称: Anti-Phospho-PLK1 (Thr210)/FITC
抗体货号: HZ-3344R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/9 14:23:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-Phospho-PLK1 (Thr210)/FITC Conjugated antibody 

FITC标记的***酸化丝/苏氨酸蛋白激酶Plk1抗体

 

英文名称 Anti-Phospho-PLK1 (Thr210)/FITC
中文名称 FITC标记的***酸化丝/苏氨酸蛋白激酶Plk1抗体
别    名 PLK1 (phospho T210); p-PLK1 (phospho T210); PLK1 (Phospho-Thr210); PLK1 (Phospho Thr210); p-PLK1 (Thr210); p-PLK1 (T210); Polo-Like Kinase(phospho T210); PLK 1; PLK; polio like kinase; Polo like kinase 1; Polo-like kinase 1; Serine/threonine protein kinase 13; Serine/threonine protein kinase PLK1; Serine/threonine-protein kinase; STPK 13; STPK13; Polo like kinase kinase; Cell cycle regulated protein kinase; PLK-1; plk1; PLK1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 肿瘤  细胞生物  免疫学  信号转导  转录调节因子  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 68kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human PLK1 around the phosphorylation site of Thr210
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
PLK1 (polo-like kinase 1) is a member of the serine/threonine protein kinase family, cdc5/polo subfamily. PLK1 contains two polo box domains with a predicted molecular weight of 68 kDa. PLK1 has been shown to regulate cdc2/cyclin B through phosphorylation and activation of cdc25c phosphatase. PLK1 is modified by phosphorylation at Threonine 210. PLK1 may also be required for cell division. Depletion of PLK1 results in apoptosis and deregulation of expression of PKL1 is correlated with development of many malignancies.

Function:
Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS. Phosphorylates NEDD1. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylates both ECT2 and RACGAP1, and thereby stimulates their interaction that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2.

Subunit:
Interacts with CEP170 and EVI5. Interacts and phosphorylates ERCC6L. Interacts with FAM29A. Interacts with SLX4/BTBD12 and TTDN1. Interacts with BUB1B. Interacts (via POLO-box domain) with the phosphorylated form of BUB1, MLF1IP and CDC25C. Interacts with isoform 3 of SGOL1. Interacts with BORA, KIF2A and AURKA. Interacts with TOPORS and CYLD. Interacts with ECT2; the interaction is stimulated upon phosphorylation of ECT2 on 'Thr-444'. Interacts with PRC1.

Subcellular Location:
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, centrosome. Midbody.

Tissue Specificity:
Placenta and colon.

Post-translational modifications:
Catalytic activity is enhanced by phosphorylation of Thr-210. Phosphorylation at Thr-210 is first detected on centrosomes in the G2 phase of the cell cycle, peaks in prometaphase and gradually disappears from centrosomes during anaphase. 
Autophosphorylation and phosphorylation of Ser-137 may not be significant for the activation of PLK1 during mitosis, but may enhance catalytic activity during recovery after DNA damage checkpoint. 
Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) in anaphase and following DNA damage, leading to its degradation by the proteasome. Ubiquitination is mediated via its interaction with FZR1/CDH1. Ubiquitination and subsequent degradation prevents entry into mitosis and is essential to maintain an efficient G2 DNA damage checkpoint.

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. 
Contains 2 POLO box domains. 
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 5347 Human

Entrez Gene: 18817 Mouse

Entrez Gene: 25515 Rat

Omim: 602098 Human

SwissProt: P53350 Human

SwissProt: Q07832 Mouse

SwissProt: Q62673 Rat

Unigene: 592049 Human

Unigene: 16525 Mouse

Unigene: 11034 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

PLK1(Polo样激酶1)是丝氨酸/苏氨酸蛋白激酶家族的成员,CDC5/Polo亚家族。PLK1包含两个预测分子量为68 kDa的Polo盒结构域。PLK1已被证明通过CDC25C***酸酶的***酸化和活化来调节CDC2/cyclin B。通过苏氨酸210的***酸化修饰PLK1。细胞分裂也需要PLK1。PLK1的缺失导致细胞凋亡和PKL1表达的下调与多种恶性肿瘤的发生发展有关。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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