FITC标记的磷酸化磷酯酶Cγ2抗体-抗体-抗体-生物在线
FITC标记的磷酸化磷酯酶Cγ2抗体

FITC标记的磷酸化磷酯酶Cγ2抗体

商家询价

产品名称: FITC标记的磷酸化磷酯酶Cγ2抗体

英文名称: Anti-Phospho-PLCG 2 (Tyr1217)/FITC

产品编号: HZ-3338R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: Flow-Cyt=1:50-200 IF=1:50-200

上海沪震实业有限公司
  • 联系人 : 鲍丽雯
  • 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
  • 邮编 : 200612
  • 所在区域 : 上海
  • 电话 : 139****0749
  • 传真 : 021-60345367
  • 邮箱 : www.shzbio.net

 Rabbit Anti-Phospho-PLCG 2 (Tyr1217)/FITC Conjugated antibody

FITC标记的磷酸化磷酯酶Cγ2抗体

 

英文名称 Anti-Phospho-PLCG 2 (Tyr1217)/FITC
中文名称 FITC标记的磷酸化磷酯酶Cγ2抗体
别    名 PLCG 2 (phospho Y1217); p-PLCG 2 (phospho Y1217); PLCG2(phospho Y1217); Phospho-PLC γ2(Tyr1217); Phospho-PLC gamma 2/PLCG2(Tyr1217); PLC 2; PLC gamma 2; PLC IV; PLCG2; 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 2; EC 3.1.4.11; Phosphoinositide phospholipase C; Phospholipase C gamma 2; Phospholipase C, gamma 2 (phosphatidylinositol specific); PLCG2_HUMAN.   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 磷酸化抗体 
研究领域 肿瘤  免疫学  信号转导  转录调节因子  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, 
产品应用 Flow-Cyt=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 139kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human PLC gamma 2 around the phosphorylation site of Tyr1217
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide specific phospholipase C enzymes, C beta is regulated by heterotrimeric G protein coupled receptors, while the closely related C gamma 1 and C gamma 2 enzymes are controlled by receptor tyrosine kinases. The C gamma 1 and C gamma 2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3. 

Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

Subunit:
Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity).

Post-translational modifications:
Phosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity.

Similarity:
Contains 1 C2 domain. 
Contains 1 PH domain. 
Contains 1 PI-PLC X-box domain. 
Contains 1 PI-PLC Y-box domain. 
Contains 2 SH2 domains. 
Contains 1 SH3 domain.

Database links:

Entrez Gene: 5336 Human

Entrez Gene: 234779 Mouse

Entrez Gene: 29337 Rat

Omim: 600220 Human

SwissProt: P16885 Human

SwissProt: Q8CIH5 Mouse

SwissProt: P24135 Rat

Unigene: 413111 Human

Unigene: 192699 Mouse

Unigene: 9751 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application
   

磷脂酶C家族的酶催化磷脂水解以产生脂头基团的二酰甘油和水溶性磷酸化衍生物。许多这些酶对磷酸肌醇具有特异性。在肌醇磷脂特异性磷脂酶C酶中,Cβ受异三聚体G蛋白偶联受体调节,而紧密相关的Cγ1和Cγ2酶由受体酪氨酸激酶控制。Cγ1和Cγ2酶由磷脂酶结构域组成,侧翼区域与Src癌基因产物SH2和SH3的非催化结构域同源。