FITC标记的磷酸化3磷酸肌醇依赖性蛋白激酶1上海沪震实业有限公司

性能参数

产品名称: FITC标记的磷酸化3磷酸肌醇依赖性蛋白激酶1
英文名称: Anti-Phospho-PDK1(Ser241)/FITC
抗体货号: HZ-3327R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/10 9:12:00
详细资料:  实验方法技术资料
浏览人数:7
诚信指数:824点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
点此求购
在线QQ: 我是2043711056,请问我有什么可以帮到您呢?
生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
邮件:
公司展台:
在线QQ:
我是2043711056,请问我有什么可以帮到您呢?
扫一扫,关注我们

产品详细描述

 Rabbit Anti-Phospho-PDK1(Ser241)/FITC Conjugated antibody

FITC标记的***酸化3***酸肌醇依赖性蛋白激酶1

 

英文名称 Anti-Phospho-PDK1(Ser241)/FITC
中文名称 FITC标记的***酸化3***酸肌醇依赖性蛋白激酶1
别    名 PDK1(Phospho-Ser241); PDPK1 (phospho S241); PDPK1(phospho-S241); 3 phosphoinositide dependent protein kinase 1; hPDK 1; hPDK1; MGC20087 MGC35290; PDK 1; PDPK 1; PDPK1; PkB kinase; PkB kinase like gene 1; PkB like 1; PkB like; PRO0461; PDPK1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 肿瘤  免疫学  神经生物学  信号转导  细胞凋亡  转录调节因子  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 61kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human PDPK1 around the phosphorylation site of Ser241
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms. 

Function:
Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.

Subunit:
Interacts with NPRL2.

Subcellular Location:
Cytoplasm. Membrane. Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.

Tissue Specificity:
Appears to be expressed ubiquitously.

Post-translational modifications:
Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation.

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily.
Contains 1 PH domain.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 5170 Human

Entrez Gene: 18607 Mouse

Entrez Gene: 81745 Rat

Omim: 605213 Human

SwissProt: O15530 Human

SwissProt: Q9Z2A0 Mouse

SwissProt: O55173 Rat

Unigene: 459691 Human

Unigene: 10504 Mouse

Unigene: 10905 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

PDK1是蛋白激酶B(PKB)的上游激酶,通过与3,4,5三***酸***脂酰肌醇作用激活相邻的PKB分子

PDK1(3***酸肌醇依赖性蛋白激酶1)***酸化AGC激酶。PDK1通过激活环中的关键苏氨酸残基的***酸化激活常规PKC和PKCζ。PDK1还在***脂酰肌醇-3,4-,5-三***酸存在下在苏氨酸308上***酸化Protein Kinase B(PKB)。活性AKT失活糖原合成酶激酶3(GSK3),最终导致糖原合酶的去***酸化和活化和糖原合成的刺激。由于PDK在胰岛素诱导的糖原合成和PKC活化中发挥的作用,它是代谢药物研究的潜在重要靶点。有三个命名的异构体。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

查看FITC标记的磷酸化3磷酸肌醇依赖性蛋白激酶1产品的用户还对以下产品感兴趣

暂无

ADVERTISEMENT

找不到您所需的产品,发布求购试试?

标题:*
描述:
姓名:*
Email:*
单位:*
电话:*
地址:*
邮编:
资料: 需要 不需要
报价: 需要 不需要