Rabbit Anti-Phospho-PBK (Thr9)/FITC Conjugated antibody
|别 名||PBK (phospho T9); PBK (phospho Thr9); Cancer/testis antigen 84; CT84; FLJ14385; Lymphokine activated killer T cell originated protein kinase; MAPKK like protein kinase; PDZ-binding-kinase/T-LAK cell-originated protein kinase; Nori 3; Nori3; PDZ binding kinase; Serine/threonine protein kinase; Spermatogenesis related protein kinase; SPK; T LAK cell originated protein kinase; TOPK.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子 激酶和***酸酶|
|交叉反应||Human, Mouse, Rat,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||36kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthesised phosphopeptide derived from human PBK/TOPK around the phosphorylation site of Thr9|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.
Interacts with DLG1 and TP53.
Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.
Phosphorylated; in a cell-cycle dependent manner at mitosis.
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Contains 1 protein kinase domain.
Entrez Gene: 55872 Human
Omim: 611210 Human
SwissProt: Q96KB5 Human
Unigene: 104741 Human
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PBK/TOPK是一种新近发现的丝-苏氨酸激酶,属于MAPKK分子家族成员，具有参与调控恶性肿瘤细胞的增殖和周期变化, 促进肿瘤细胞转化, 并且通过MAPKK信号通路参与调控细胞DNA损伤修复
该基因编码与双特异性丝裂原活化蛋白激酶激酶（MAPKK）家族相关的丝氨酸/苏氨酸蛋白激酶。有证据表明，有丝分裂***酸化是必需的，其催化活性。编码的蛋白质可能参与淋巴细胞的活化和支持睾丸功能，在精子发生过程中起到暗示的作用。该基因的过度表达与肿瘤发生有关。选择性剪接导致多个转录变体。[ RefSeq，JUL 2013 ]