FITC标记的磷酸化p21激活激酶6抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的磷酸化p21激活激酶6抗体
英文名称: Anti-Phospho-PAK6(Ser560)/FITC
抗体货号: HZ-3314R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: 
更新时间: 2018/8/10 9:32:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-Phospho-PAK6(Ser560)/FITC Conjugated antibody 

FITC标记的***酸化p21激活激酶6抗体

 

英文名称 Anti-Phospho-PAK6(Ser560)/FITC
中文名称 FITC标记的***酸化p21激活激酶6抗体
别    名 Phospho-PAK6(Ser560); PAK4 + PAK5 + PAK6 (phospho S474 + S602 + S560); CDKN1A activated kinase 6; Serine/threonine-protein kinase PAK 6; p21 activated protein kinase 6; p21 protein (Cdc42/Rac)-activated kinase 6; p21(CDKN1A) activated kinase 6; p21-ACTIVATED KINASE 6; p21activated kinase 6; PAK 5; PAK 6; PAK5; Serine threonine protein kinase PAK 6; Serine/threonine protein kinase PAK 6; Serine/threonine protein kinase PAK6; EC 2.7.1.37; PAK-5; PAK-6; Pak6; PAK6_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 肿瘤  免疫学  信号转导  细胞凋亡  转录调节因子  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 75kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human PAK6 around the phosphorylation site of Ser560
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.

Function:
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.

Subunit:
Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with the androgen receptor AR and the estrogen receptor ESR1. Interacts with IQGAP1 and PPM1B.

Subcellular Location:
Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.

Tissue Specificity:
Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast.

Post-translational modifications:
Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation.

Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 
Contains 1 CRIB domain.

Database links:

Entrez Gene: 56924 Human

Omim: 608110 Human

SwissProt: Q9NQU5 Human

Unigene: 513645 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

该基因编码与p21活化激酶(PAK)家族成员具有高度序列相似性的蛋白质。该家族的蛋白质是RAC/CDC42相关的STE20样SE/THR蛋白激酶,其特征在于高度保守的氨基末端CDC42/Rac相互作用结合(CRIB)结构域和羧基末端激酶结构域。PAK激酶参与多种细胞过程的调节,包括细胞骨架重排、凋亡和MAP激酶信号通路。该基因编码的蛋白质与雄***受体(AR)相互作用,雄***受体是一种类固醇***依赖性转录因子,对男性的性别分化和发育具有重要意义。p21活化蛋白激酶6基因在睾丸和前列腺组织中高表达,编码蛋白与雄***共同作用于细胞核内。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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