FITC标记的p21激活激酶4抗体上海沪震实业有限公司

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产品名称: FITC标记的p21激活激酶4抗体
英文名称: Anti-PAK4/FITC
抗体货号: HZ-3517R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: 
更新时间: 2018/8/10 9:33:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-PAK4/FITC Conjugated antibody

FITC标记的p21激活激酶4抗体

 

英文名称 Anti-PAK4/FITC
中文名称 FITC标记的p21激活激酶4抗体
别    名 p21 activated kinase 4; p21(CDKN1A) activated kinase 4; PAK 4; Protein kinase related to S.cerevisiae STE20 effector for Cdc42Hs; Serine threonine kinase PAK 4; Serine/threonine protein kinase PAK 4; Serine/threonine protein kinase PAK4; KIAA1142; PAK4_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  信号转导  细胞凋亡  转录调节因子  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, 
产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 64kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PAK4
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
p21-activated kinases (PAKs) belong to the family of serine/threonine kinases involved in the control of various cellular processes, including the cell cycle, dynamics of the cytoskeleton, apoptosis, oncogenic transformation, and transcription. All PAK family members are characterized by the presence of p21-binding domain. p21-activated kinases are regulated by the small GTP-binding proteins Rac and Cdc42, and lipids, which stimulate autophosphorylation and phosphorylation of exogenous substrates. Serine (Ser-474) is the likely autophosphorylation site in the kinase domain of PAK4 in vivo. Phosphospecific antibodies directed against serine 474 detect activated PAK4 on the Golgi membrane when PAK4 is co-expressed with activated Cdc42. Current data strongly implicates PAK-4 in oncogenesis. PAK4 is frequently overexpressed in human tumor cell lines of various tissue origins.

Function:
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.

Subunit:
Interacts with FGFR2 and GRB2. Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and weakly with RAC1. 

Subcellular Location:
Cytoplasm. Note=Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways.

Tissue Specificity:
Highest expression in prostate, testis and colon. 

Post-translational modifications:
Autophosphorylated on serine residues when activated by CDC42/p21. 
Phosphorylated on tyrosine residues upon stimulation of FGFR2.

Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 
Contains 1 CRIB domain. 
Contains 1 protein kinase domain. 

Database links:

Entrez Gene: 10298 Human

Entrez Gene: 70584 Mouse

Entrez Gene: 292756 Rat

Omim: 605451 Human

SwissProt: O96013 Human

SwissProt: Q8BTW9 Mouse

Unigene: 20447 Human

Unigene: 21876 Mouse

Unigene: 18543 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

丝氨酸/苏氨酸蛋白激酶4 (PAK4)是新发现的一类蛋白因子,在细胞信号转导过程中起很重要的作用, Pak4常在人体的多种组织器官的肿瘤细胞中呈现过表达,他的丝氨酸位点很可能是Pak4酶活性区域中的自身***酸化位点,丝氨酸到谷氨酸位点的突变体促使其获得了酶活性。在肿瘤遗传学、细胞癌变、细胞凋亡等一些重要的细胞生物学研究中,具有重要的意义。
   
   

P21活化激酶(PAKs)属于丝氨酸/苏氨酸激酶家族,参与多种细胞过程的调控,包括细胞周期、细胞骨架的动态、细胞凋亡、致癌转化和转录。所有PAK家族成员的特征是存在p21结合结构域。P21活化的激酶受小GTP结合蛋白Rac和CDC42和脂质的调节,这些脂质刺激外源底物的自身***酸化和***酸化。Serine(Ser-47)是体内PAK4激酶结构域中可能的***酸化位点。针对丝氨酸474的***特异性抗体在活化的CDC42共表达时,在高尔基体膜上检测活化的PAK4。目前的数据强烈地暗示了PAK-4在肿瘤发生中的作用。PAK4在多种组织来源的人肿瘤细胞系中经常被过度表达。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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