FITC标记的糖类应答元件结合蛋白ChREBP抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的糖类应答元件结合蛋白ChREBP抗体
英文名称: Anti-WBSCR14/FITC
抗体货号: HZ-3516R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/10 9:49:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-WBSCR14/FITC Conjugated antibody

FITC标记的糖类应答元件结合蛋白ChREBP抗体

 

英文名称 Anti-WBSCR14/FITC
中文名称 FITC标记的糖类应答元件结合蛋白ChREBP抗体
别    名 ChREBP; bHLHd14; Carbohydrate responsive element binding protein; MIO; MLX interacting protein like; Mlx interactor; MLXIPL; MONDOB; WBSCR 14; WBSCR14; Williams Beuren syndrome chromosome region 14; Williams Beuren syndrome chromosome region 14 protein; WS basic helix loop helix leucine zipper protein; WS bHLH; MLXPL_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  心血管  免疫学  信号转导  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 93kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human WBSCR14/ChREBP
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
ChREBP (Carbohydrate responsive element binding protein) is a transcription factor playing a critical role in the nutrient and hormonal regulation of genes encoding enzymes of glucose metabolism and lipogenesis pathways. It contains several domains including a nuclear localization signal (NLS) near the N-terminus, polyproline domains, a basic helix-loop-helix leucine zipper (b/HLH/Zip) and a leucine zipper like (zip-like) domain. ChREBP is ubiquitously detected in various tissues, with highest expression in liver, kidney and white and brown adipose tissue. Under basal conditions ChREBP is localized in the cytosol, translocating into the nucleus upon high glucose stimulation following its dephosphorylation of phospho-serine 196.

Function:
Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity).

Subunit:
Binds DNA as a heterodimer with TCFL4/MLX.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in liver, heart, kidney, cerebellum and intestinal tissues.

Post-translational modifications:
Phosphorylation at Ser-556 by AMPK inactivates the DNA-binding activity (By similarity).

DISEASE:
Note=WBSCR14 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of WBSCR14 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.

Database links:

Entrez Gene: 51085 Human

Omim: 605678 Human

SwissProt: Q9NP71 Human

Unigene: 647055 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

ChREBP(又称碳水化合物反应元件结合蛋白)是葡萄糖信号途径中的一个新的转录因子,在哺乳动物体内可结合到糖酵解和脂肪合成酶相关基因启动子区的糖类应答元件(ChRE)上, 在他们的共同作用下,可调节糖酵解和脂肪合成酶相关基因的表达
   
   

ChREBP(碳水化合物应答元件结合蛋白)是一种转录因子,在葡萄糖代谢和脂生成途径酶基因的营养和调节中起着关键作用。它包含几个域,包括近端的核定位信号(NLS)、聚脯氨酸结构域、基本螺旋环-螺旋-亮氨酸拉链(B/HLH/ZIP)和亮氨酸拉链状(zip like)域。CHRBP广泛存在于多种组织中,在肝脏、肾脏和白棕色脂肪组织中均有最高表达。在碱性条件下,ChREBP被定位在细胞质中,在高葡萄糖刺激下***酸化丝氨酸196去***酸化后进入细胞核。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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