FITC标记的肠道分化干细胞MATH-1蛋白抗体上海沪震实业有限公司

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产品名称: FITC标记的肠道分化干细胞MATH-1蛋白抗体
英文名称: Anti-MATH1/FITC
抗体货号: HZ-3522R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/10 9:50:00
详细资料:  实验方法技术资料
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诚信指数:1026点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-MATH1/FITC Conjugated antibody

FITC标记的肠道分化干细胞MATH-1蛋白抗体

 

英文名称 Anti-MATH1/FITC
中文名称 FITC标记的肠道分化干细胞MATH-1蛋白抗体
别    名 ATH 1; ATH1; ATOH 1; ATOH1; Atonal homolog 1; Atonal protein homolog 1; HATH 1; HATH1; Helix loop helix protein hATH 1; MATH 1; MATH1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  发育生物学  神经生物学  干细胞  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 38kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MATH1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The Drosophila atonal gene produces a protein with basic helix loop helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system. Mammalian atonal homolog 1 (MATH-1) is a helix-loop-helix (HLH) transcription factor that is structurally homologous to the product of the Drosophila proneural gene atonal. MATH-1, so known as Atoh1, Ath1 or HATH-1, is a 351 amino acid protein with an atonal-related basic HLH domain. In mice, expression of MATH-1 takes place by embryonic day 9.5 and initially localizes to the cranial ganglions and the dorsal part of the central nervous system. Prominent expression of MATH-1 is in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by day 18 and is undetectable in the adult nervous system. It is suggested that MATH-1 may play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.

Function:
MATH1 protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. MATH1 is neural-specific and is switched on during differentiation into neuroectoderm.
Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. May play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.

Subcellular Location:
Nucleus.

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.

Database links:

Entrez Gene: 474 Human

Entrez Gene: 11921 Mouse

Entrez Gene: 500156 Rat

Omim: 601461 Human

SwissProt: Q92858 Human

SwissProt: P48985 Mouse

Unigene: 532680 Human

Unigene: 57229 Mouse

Unigene: 218507 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

果蝇无定形基因产生一种具有基本螺旋-环-螺旋(BHLH)结构域的蛋白质,其在果蝇神经系统的发育中起着至关重要的作用。哺乳动物无调同源物1(MATH-1)是一种螺旋环螺旋(HLH)转录因子,其结构与果蝇原代基因ATONOND的结构同源。MATH-1,被称为ATOH1,Ath1或HAth-1,是一个351氨基酸的蛋白质,与无环相关的基本HLH结构域。在小鼠中,MATH-1的表达发生在胚胎第9.5天,最初定位于颅神经节和中枢神经系统的背侧部分。MATH-1的显著表达在中枢神经系统的背侧,但在第18天仅限于小脑的外颗粒层,在***神经系统中是不可检测的。提示MATH-1可能通过激活E盒依赖性转录在神经细胞亚群的分化中发挥作用。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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