FITC标记的DNA结合抑制因子2抗体
产品名称： FITC标记的DNA结合抑制因子2抗体
英文名称： Anti-ID2/FITC
产品编号： HZ-3515R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-ID2/FITC Conjugated antibody
FITC标记的DNA结合抑制因子2抗体
| 英文名称 | Anti-ID2/FITC |
| 中文名称 | FITC标记的DNA结合抑制因子2抗体 |
| 别 名 | ID2; GIG-8; GIG8; GIG 8; Helix loop helix protein ID2; ID2A; ID-2; ID2H; Inhibitor of differentiation 2; Inhibitor of DNA binding 2; Inhibitor of DNA binding 2, dominant negative helix loop helix protein; MGC26389; bHLHb26; Cell growth inhibiting gene 8; DNA binding protein inhibitor ID 2; BHLHB26; ID2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 染色质和核信号 信号转导 细胞凋亡 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 15kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GIG8/ID2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, and may play a role in negatively regulating cell differentiation. Members of the ID family are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. They inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner, by suppressing their heterodimerization partners through the HLH domains. Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression. Subunit: Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5. Interacts with NR0B2. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Highly expressed in early fetal tissues, including those of the central nervous system. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Database links: Entrez Gene: 3398 Human Entrez Gene: 15902 Mouse Omim: 600386 Human SwissProt: Q02363 Human SwissProt: P41136 Mouse Unigene: 180919 Human Unigene: 34871 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
由该基因编码的蛋白质属于DNA结合（Id）家族的抑制剂，并可能在负调节细胞分化中起作用。ID家族的成员是包含螺旋-环-螺旋（HLH）域但不是基本域的转录调节子。它们通过抑制HLH结构域的异源二聚体，从而抑制碱性螺旋-环-螺旋转录因子在显性负性方式中的功能。