FITC标记的磷酸化孤儿核受体蛋白Nur77抗体上海沪震实业有限公司

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产品名称: FITC标记的磷酸化孤儿核受体蛋白Nur77抗体
英文名称: Anti-Phospho-Nur77(Ser351)/FITC
抗体货号: HZ-
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/10 9:55:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Phospho-Nur77(Ser351)/FITC Conjugated antibody 

FITC标记的***酸化孤儿核受体蛋白Nur77抗体

 

英文名称 Anti-Phospho-Nur77(Ser351)/FITC
中文名称 FITC标记的***酸化孤儿核受体蛋白Nur77抗体
别    名 NR4A1(phospho S351); NUR77 (phospho S351); p-NUR77 (phospho S351); GFRP 1; GFRP; GFRP1; Growth factor inducible nuclear protein N10; Growth Factor Inducible Nuclear Protein NP10; Growth Factor Response Protein 1; Hbr1; HMR; Hormone Receptor; MGC9485; N10; N10 nuclear protein; NAK 1; NAK1; NGFIB; NP 10; NP10; NR4A1; Nuclear hormone receptor NUR/77; Nuclear Hormone Receptor TR3; Nuclear Receptor Subfamily 4 Group A Member 1; NUR77; Orphan nuclear receptor HMR; Orphan nuclear receptor NR4A1; ST 59; ST59; Steroid receptor TR3; TR 3; TR3; TR3 orphan receptor; Early response protein NAK1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 肿瘤  心血管  细胞生物  免疫学  染色质和核信号  神经生物学  信号转导  细胞凋亡  转录调节因子  糖尿病  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 66kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Nur77 around the phosphorylation site of Ser351
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Function:
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.

Subunit:
Binds DNA as a monomer. Interacts with GADD45GIP1.

Subcellular Location:
Nucleus.

Tissue Specificity:
Fetal muscle and adult liver, brain and thyroid.

Post-translational modifications:
Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli.

Similarity:
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

Database links:

Entrez Gene: 3164 Human

Entrez Gene: 15370 Mouse

Entrez Gene: 79240 Rat

Omim: 139139 Human

SwissProt: P22736 Human

SwissProt: P12813 Mouse

SwissProt: P22829 Rat

Unigene: 524430 Human

Unigene: 119 Mouse

Unigene: 10000 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

孤儿核受体蛋白Nur77是早期反应转录因子之一,多种刺激因子如缺氧可诱导其迅速表达,Nur77参与调控细胞增殖、存活、分化等过程。这类核受体是体内广泛分布的配体依赖性的转录因子,通过调控基因协调表达,在机体的生长发育、新陈代谢,细胞分化及体内许多生长发育过程中发挥重要作用,其功能障碍将导致一系列疾病的发生,如;癌症、糖尿病、肥胖、不孕不育等等
   

该基因编码类固醇甲状腺类视黄醇受体超家族成员。表达是由植物血凝集素诱导人淋巴细胞和血清刺激被捕的成纤维细胞。编码的蛋白质起核转录因子的作用。蛋白质从细胞核向线粒体的移位诱导细胞凋亡。该基因已发现编码不同亚型的多个转录变体。[ RefSeq,2011月1日]

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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