FITC标记的膜相关蛋白Numb抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的膜相关蛋白Numb抗体
英文名称: Anti-NUMB/FITC
抗体货号: HZ-3510R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/10 9:58:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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邮编:
200612
电话:
021-60345367
传真:
021-31320307
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陈先生
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上海·中国-上海
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产品详细描述

 Rabbit Anti-NUMB/FITC Conjugated antibody 

FITC标记的膜相关蛋白Numb抗体

 

英文名称 Anti-NUMB/FITC
中文名称 FITC标记的膜相关蛋白Numb抗体
别    名 c14_5527; C14orf41; FLJ31314; h Numb; h-Numb; Numb; Numb homolog (Drosophila); Numb homolog; Numb protein homolog; NUMB_HUMAN; Protein numb homolog; Protein S171; S171.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  神经生物学  干细胞  细胞膜受体  细胞表面分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 70kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NUMB
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Function:
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

Subunit:
Interacts with CDH1 and TFAP2B (By similarity). Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.

Subcellular Location:
Membrane; Peripheral membrane protein.

Post-translational modifications:
Phosphorylated on Ser-276 and Ser-295 by CaMK1. 
Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation. Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.

Similarity:
Contains 1 PID domain.

Database links:

Entrez Gene: 8650 Human

Entrez Gene: 18222 Mouse

Entrez Gene: 29419 Rat

Omim: 603728 Human

SwissProt: P49757 Human

SwissProt: Q9QZS3 Mouse

SwissProt: Q2LC84 Rat

Unigene: 654609 Human

Unigene: 714879 Human

Unigene: 4390 Mouse

Unigene: 102078 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

膜相关蛋白Numb是细胞命运决定因子:在细胞有丝分裂期,Numb选择性地分布于细胞的一侧,在胞质分裂后则被分配于一个子细胞,Numb通过抑制跨膜受体Notch而发挥作用, Numb信号途径在前体细胞的神经元调控方面起着重要作用
   

该基因编码的蛋白在发育过程中对细胞命运的测定起着一定的作用。编码的蛋白质,其降解以蛋白酶体依赖的方式由MDM2诱导,是一种膜结合蛋白,已被证明与EPS15、LNX1和Notch1相关。已经发现了四个编码不同亚型的转录本变体。[由RefSeq提供]。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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