FITC标记的谷氨酸受体2B抗体-抗体-抗体-生物在线
FITC标记的谷氨酸受体2B抗体

FITC标记的谷氨酸受体2B抗体

商家询价

产品名称: FITC标记的谷氨酸受体2B抗体

英文名称: Anti-NMDAR2B/FITC

产品编号: HZ-3307R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: Flow-Cyt=1:50-200 IF=1:50-200

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 Rabbit Anti-NMDAR2B/FITC Conjugated antibody 

FITC标记的谷氨酸受体2B抗体

 

英文名称 Anti-NMDAR2B/FITC
中文名称 FITC标记的谷氨酸受体2B抗体
别    名 AW490526; Glutamate [NMDA] receptor subunit epsilon 2; Glutamate [NMDA] receptor subunit epsilon-2; Glutamate Receptor Ionotropic N Methyl D Aspartate 2B; Glutamate Receptor Ionotropic N Methyl D Aspartate subunit 2B; Glutamate receptor ionotropic NMDA2B; Glutamate receptor subunit epsilon 2; Glutamate receptor, ionotropic, NMDA2B (epsilon 2); GRIN 2B; GRIN2B; hNR 3; hNR3; MGC142178; MGC142180; N methyl D asparate receptor channel subunit epsilon 2; N METHYL D ASPARTATE RECEPTOR CHANNEL SUBUNIT EPSILON 2; N methyl D aspartate receptor subtype 2B; N methyl D aspartate receptor subunit 2B; N methyl D aspartate receptor subunit 3; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NMDA NR2B; NMDA R2B; Nmdar2b; NMDE2; NMDE2_MOUSE; NME2; NR2B; NR3.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  神经生物学  信号转导  转录调节因子  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, 
产品应用 Flow-Cyt=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 163kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse NMDAR2B
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008].

Function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death.

Subunit:
Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL, DLG4 and MAGI3 (By similarity). Interacts with HIP1 and NETO1. Interacts with DAPK1.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Post-translational modifications:
Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity.

Similarity:
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. 

Database links:

Entrez Gene: 2904 Human

Entrez Gene: 14812 Mouse

Entrez Gene: 24410 Rat

Omim: 138252 Human

SwissProt: Q13224 Human

SwissProt: Q01097 Mouse

SwissProt: Q00960 Rat

Unigene: 654430 Human

Unigene: 436649 Mouse

Unigene: 9711 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

谷氨酸受体(NR2B)是脊椎动物中枢神经系统兴奋型神经传递的主要介质。在突触可塑性极大脑学习及记忆功能方面起关键作用
   
   

N-甲基-D-天冬氨酸(NMDA)受体是一类离子型谷氨酸受体。NMDA受体通道已被证明参与长时程增强,突触传递的效率依赖于某些类型的记忆和学习的活动依赖性增加。NMDA受体通道是由三个不同亚基组成的异构体:NR1(GRIN1),NR2(GRAN2A,GRAN2B,GRAN2C,或GRAN2D)和NR3(GRAN3A或GRAN3B)。NR2亚基作为谷氨酸的激动剂结合位点。该受体是哺乳动物脑中主要的兴奋性神经递质受体。[ RefSeq,JUL 2008 ]提供。