FITC标记的磷酸化谷氨酸受体2A抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的磷酸化谷氨酸受体2A抗体
英文名称: Anti-Phospho-NMDAR2A (Tyr1246)/FITC
抗体货号: HZ-3304R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/10 10:06:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Phospho-NMDAR2A (Tyr1246)/FITC Conjugated antibody

FITC标记的***酸化谷氨酸受体2A抗体

 

英文名称 Anti-Phospho-NMDAR2A (Tyr1246)/FITC
中文名称 FITC标记的***酸化谷氨酸受体2A抗体
别    名 NMDAR2A (phospho T1246) ; p-NMDAR2A (phospho T1246) ; GRIN2B; Glutamate [NMDA] receptor subunit epsilon 1; Glutamate [NMDA] receptor subunit epsilon 2; Glutamate [NMDA] receptor subunit epsilon-1; Glutamate [NMDA] receptor subunit epsilon-2; GRIN2A; hNR2A; hNR3; N methyl D aspartate receptor subtype 2A; N methyl D aspartate receptor subtype 2B; N-methyl D-aspartate receptor subtype 2A; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NMDAR2A; NMDAR2B; NMDE2_HUMAN; NR2A; NR2B; NR3.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 细胞生物  免疫学  神经生物学  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 164kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human NMDAR2A around the phosphorylation site of Tyr1246
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).

Subunit:
Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4. Interacts with HIP1 and NETO1 (By similarity). Interacts with MAGI3. Interacts with DAPK1 (By similarity).

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. 

Similarity:
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily.

Database links:

Entrez Gene: 2903 Human

Entrez Gene: 14811 Mouse

Entrez Gene: 24409 Rat

Omim: 138253 Human

SwissProt: Q12879 Human

SwissProt: P35436 Mouse

SwissProt: Q00959 Rat

Unigene: 411472 Human

Unigene: 2953 Mouse

Unigene: 9710 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

N-甲基-D-天门冬氨酸(NMDA)受体是一类离子型谷氨酸门控离子通道。这些受体已被证明参与长时程增强,突触传递的效率依赖于某些类型的记忆和学习的活动依赖性增加。NMDA受体通道是由关键受体亚基NMDAR1(GRIN1)和4个nMdAR2亚基中的1个或多个组成的异构体:NMDA 2A(GRAN2A)、NMDA 2B(GRAN2B)、NMDA 2C(GRAN2C)和NMDA 2D(GRAN2D)。另一种编码不同的异构体的剪接转录变体已被发现用于该基因。[ RefSeq,Aug 2008提供]

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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