FITC标记的磷酸化离子型谷氨酸受体1抗体上海沪震实业有限公司

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产品名称: FITC标记的磷酸化离子型谷氨酸受体1抗体
英文名称: Anti-Phospho-NMDAR1(Ser896)/FITC
抗体货号: HZ-3302R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/8 14:29:00
详细资料:  实验方法技术资料
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诚信指数:1026点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Phospho-NMDAR1(Ser896)/FITC Conjugated antibody

FITC标记的***酸化离子型谷氨酸受体1抗体

 

英文名称 Anti-Phospho-NMDAR1(Ser896)/FITC
中文名称 FITC标记的***酸化离子型谷氨酸受体1抗体
别    名 NMDAR1 C1 (phospho S896); p-NMDAR1 C1 (phospho S896); NMDAR1(Phospho-Ser896); NMDAR1(Phospho-S896); NMDAR1 C1 (phospho S896); p-NMDAR1(S896); p-NMDAR1(Ser896); NMDA-NR1; N-Methyl-d-Asprtate receptor 1; GRIN1; NMDA1; NR1; Glutamate [NMDA] receptor subunit zeta 1; Glutamate receptor ionotropic N methyl D aspartate 1; Grin 1; Grin1; N methyl D aspartate receptor channel; N-methyl-D-aspartate receptor; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; NMDA 1; NMDA NR1; NMDA R1; NMDA receptor 1; NMDA1; NMDAR 1; NMDAR; NR 1; NMDZ1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 细胞生物  免疫学  神经生物学  信号转导  转录调节因子  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 103kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human NMDAR1 around the phosphorylation site of Ser896
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Neuronal Marker
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

Function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.

Subunit:
Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ. Interacts with LRFN1 and LRFN2. Interacts with MYZAP.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Post-translational modifications:
NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.

DISEASE:
Defects in GRIN1 are the cause of mental retardation autosomal dominant type 8 (MRD8) [MIM:614254]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.

Similarity:
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.

Database links:

Entrez Gene: 2902 Human

Entrez Gene: 14810 Mouse

Entrez Gene: 24408 Rat

Omim: 138249 Human

SwissProt: Q05586 Human

SwissProt: P35438 Mouse

SwissProt: P35439 Rat

Unigene: 558334 Human

Unigene: 278672 Mouse

Unigene: 9840 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

神经细胞标志物
(NMDAR1)N-甲基-D-天门冬氨酸受体(NMDAR)是兴奋性氨基酸受体亚型之一,是由NMDAR1与不同的NMDAR2亚基组成的异聚体。
NMDAR1又称GluR1 (Glutamate Receptor 1)近年实验研究发现,许多NMDAR拮抗药均具有镇痛活性,表明NMDAR在痛觉传递中具有重要作用,这为新型镇痛药的研究开发提供了新的作用靶点

神经标记物

 

基因编码的蛋白质是由本院重症亚单位的N-甲基-D-天冬氨酸受体,谷氨酸受体通道超家族成员的蛋白质配合物的组成,这是安排形成多元生理配体门控离子通道。论文的关键,即在生理作用的可塑性被认为是一个synapses学院,underlie记忆和学习。细胞特异性因子是不同的isoforms控制思想表达,可能对生理功能多样性的位置。也spliced转录变异已经描述。RefSeq提供的2008年7月[,]

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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