Rabbit Anti-Phospho-NMDAR1 (Ser890)/FITC Conjugated antibody
|别 名||NMDAR1 (phospho S890); p-NMDAR1 (phospho S890); NMDA-NR1; N-Methyl-d-Asprtate receptor 1; GRIN1; NMDA1; NR1; Glutamate [NMDA] receptor subunit zeta 1; Glutamate receptor ionotropic N methyl D aspartate 1; Grin 1; Grin1; N methyl D aspartate receptor channel; N-methyl-D-aspartate receptor; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; NMDA 1; NMDA NR1; NMDA R1; NMDA receptor 1; NMDA1; NMDAR 1; NMDAR; NR 1; NMDZ1_HUMAN.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||细胞生物 免疫学 神经生物学 信号转导 细胞凋亡 转录调节因子 激酶和***酸酶 细胞膜受体|
|交叉反应||Human, Mouse, Rat, Chicken, Dog, Cow,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||103kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated Synthesised phosphopeptide derived from human NMDAR1 around the phosphorylation site of Ser890|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.
Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ (By similarity). Interacts with LRFN1 and LRFN2 (By similarity). Interacts with MYZAP.
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.
NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.
Defects in GRIN1 are the cause of mental retardation autosomal dominant type 8 (MRD8) [MIM:614254]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
Entrez Gene: 2902 Human
Entrez Gene: 14810 Mouse
Entrez Gene: 24408 Rat
Omim: 138249 Human
SwissProt: Q05586 Human
SwissProt: P35438 Mouse
SwissProt: P35439 Rat
Unigene: 558334 Human
Unigene: 278672 Mouse
Unigene: 9840 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
NMDAR1又称GluR1 (Glutamate Receptor 1)近年实验研究发现，许多NMDAR拮抗药均具有镇痛活性，表明NMDAR在痛觉传递中具有重要作用，这为新型镇痛药的研究开发提供了新的作用靶点
由该基因编码的蛋白质是N-甲基-D-天冬氨酸受体的关键亚基，谷氨酸受体通道超家族的成员，其是多个亚基蛋白复合物，其具有多个亚基，其被安排形成配体门控离子通道。这些亚基在突触可塑性中起着关键的作用，这被认为是记忆和学习的基础。细胞特异性因子被认为控制不同亚型的表达，可能有助于亚基的功能多样性。另外，已经描述了剪接转录变体。[ RefSeq，JUL 2008 ]