FITC标记的磷酸化蛋白激酶PKMYT1(Ser83)抗体-抗体-抗体-生物在线
FITC标记的磷酸化蛋白激酶PKMYT1(Ser83)抗体

FITC标记的磷酸化蛋白激酶PKMYT1(Ser83)抗体

商家询价

产品名称: FITC标记的磷酸化蛋白激酶PKMYT1(Ser83)抗体

英文名称: Anti-Phospho-PKMYT1 (Ser83)/FITC

产品编号: HZ-3296R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: IF=1:50-200

上海沪震实业有限公司
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Rabbit Anti-Phospho-PKMYT1 (Ser83)/FITC Conjugated antibody

FITC标记的磷酸化蛋白激酶PKMYT1(Ser83)抗体

 

英文名称 Anti-Phospho-PKMYT1 (Ser83)/FITC
中文名称 FITC标记的磷酸化蛋白激酶PKMYT1(Ser83)抗体
别    名 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Myt1 kinase; PMYT1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 磷酸化抗体 
研究领域 细胞生物  免疫学  神经生物学  信号转导  细胞凋亡  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Horse, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 54kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human PKMYT1 around the phosphorylation site of Ser83
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008]

Function:
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. 

Subunit:
Interacts with CDC2-CCNB1 complex. Can also interact with PIN1 when phosphorylated by CDC2-CCNB1. 

Subcellular Location:
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. 

Post-translational modifications:
Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity. 

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. 
Contains 1 protein kinase domain. 

Database links:

 

Entrez Gene: 9088 Human

Entrez Gene: 268930 Mouse

Entrez Gene: 287101 Rat

Omim: 602474 Human

SwissProt: Q99640 Human

SwissProt: Q9ESG9 Mouse

Unigene: 77783 Human

Unigene: 182193 Mouse

Unigene: 204349 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

由该基因编码的蛋白质是含有神经特异性锌指的DNA结合蛋白家族的成员。该蛋白与中枢神经系统的蛋白脂质蛋白的启动子区结合,并在发育中的神经系统中发挥作用。[ RefSeq,JUL 2008 ]