Rabbit Anti-phospho-SYN1(Ser553)/FITC Conjugated antibody
|别 名||SYN1(phospho-Ser553); Synapsin I (phospho S553); Synapsin I (phospho Ser553); Brain protein 4.1; SYN 1; SYN 1a; SYN 1b; SYN I; SYN1; SYN1a; SYN1b; Synapsin 1; Synapsin1; SynapsinI; Synapsin-1; SYNI; SYN1_HUMAN.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||细胞生物 免疫学 神经生物学|
|交叉反应||Human, Mouse, Rat, Dog, Pig, Rabbit,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||78kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated Synthesised phosphopeptide derived from human Synapsin I around the phosphorylation site of Ser553|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1. Isoform Ib interacts with PRNP.
Cell junction, synapse. Golgi apparatus.
Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.
Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.
Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.
Belongs to the synapsin family.
Entrez Gene: 6853 Human
Entrez Gene: 20964 Mouse
Entrez Gene: 24949 Rat
Omim: 313440 Human
SwissProt: P17600 Human
SwissProt: O88935 Mouse
SwissProt: P09951 Rat
Unigene: 225936 Human
Unigene: 439844 Mouse
Unigene: 9923 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
该基因是突触素基因家族的成员。突触蛋白编码神经元***蛋白，其与突触小泡的细胞质表面相关。家族成员具有共同的蛋白质结构域，它们参与突触发生和神经递质释放的调节，提示在一些神经精神疾病中可能发挥作用。突触蛋白家族成员在调节轴突生成和突触发生中起着重要的作用。编码的蛋白质用作几种不同蛋白激酶的底物，***酸化可在神经末梢中调节该蛋白的功能。该基因的突变可能与X连锁障碍与原发性神经元变性如雷特综合征有关。另一种编码不同的异构体的剪接转录变体已被鉴定。[ RefSeq，JUL 2008 ]