FITC标记的转录因子Tbx18抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的转录因子Tbx18抗体
英文名称: Anti-TBX18/FITC
抗体货号: HZ-4748R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: 
更新时间: 2018/8/10 10:48:00
详细资料:  实验方法技术资料
浏览人数:8
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-TBX18/FITC Conjugated antibody 

FITC标记的转录因子Tbx18抗体

 

英文名称 Anti-TBX18/FITC
中文名称 FITC标记的转录因子Tbx18抗体
别    名 T box 18; T box protein 18; T box transcription factor TBX18; T-box protein 18; T-box transcription factor TBX18; TBX18; TBX18_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  染色质和核信号  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TBX18
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
T-box transcription factors are a group of phylogenetically conserved genes that contain a uniquely defining DNA-binding domain, the T-box domain. These genes are believed to be involved in the regulation of development processes, for example the development of limbs, and it is known that haploinsufficiency of multiple T-box proteins results in severe human congenital malformation syndromes, involving craniofacial, cardiovascular, and skeletal structures. TBX 18 has been reported to be involved in numerous development processes and to act as an antiapoptotic factor.

Function:
Probable transcriptional regulator involved in developmental processes.

Subunit:
Homodimer. Can form a heterodimer with TBX15. Interacts with GATA4 AND NKX2-5. Interacts with PAX3 (By similarity). Interacts (via engrailed homology 1 repressor motif) with TLE3; this interaction represses TBX18 transcriptional activity (By similarity) (PubMed:26235987). Interacts with SIX1 (PubMed:26235987).

Subcellular Location:
Nucleus.

DISEASE:
Congenital anomalies of kidney and urinary tract 2 (CAKUT2). The disease is caused by mutations affecting the gene represented in this entry. A disorder encompassing a broad spectrum of renal and urinary tract malformations that include renal agenesis, kidney hypodysplasia, multicystic kidney dysplasia, duplex collecting system, posterior urethral valves and ureter abnormalities. Congenital anomalies of kidney and urinary tract are the commonest cause of chronic kidney disease in children.

Similarity:
Contains 1 T-box DNA-binding domain.

Database links:

Entrez Gene: 9096 Human
Entrez Gene: 76365 Mouse
Entrez Gene: 315870 Rat
Omim: 604613 Human
SwissProt: O95935 Human
SwissProt: Q9EPZ6 Mouse
Unigene: 251830 Human
Unigene: 158789 Mouse
Unigene: 161921 Rat





Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

T-box转录因子是一组系统保守的基因,包含一个独特的DNA结合结构域,即T盒结构域。这些基因被认为参与了发育过程的调节,例如四肢的发育,并且已知多个T-box蛋白的单倍不足导致严重的人类先天畸形综合征,涉及颅面、心血管和骨骼。L结构。TBX 18已被报道参与许多开发过程,并起到抗凋亡因子的作用。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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