FITC标记的肌细胞生成素抗体上海沪震实业有限公司

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产品名称: FITC标记的肌细胞生成素抗体
英文名称: Anti-Myogenin/FITC
抗体货号: HZ-3550R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/10 10:52:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Myogenin/FITC Conjugated antibody

FITC标记的肌细胞生成素抗体

 

英文名称 Anti-Myogenin/FITC
中文名称 FITC标记的肌细胞生成素抗体
别    名 MYOG; bHLHc3; cb553; MYF 4; MYF4; Myf-4; MYOG; Myogenic factor 4; Myogenic factor 4 myogenin; MYOGENIN; Myogenin myogenin factor 4; OTTHUMP00000039094; Class C basic helix-loop-helix protein 3; MYOG_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 心血管  激酶和***酸酶  结合蛋白  细胞表面分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MYOG/Myogenin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008]

Function:
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts.

Subunit:
Homodimer and heterodimer with E12; heterodimerization enhances MYOG DNA-binding and transcriptional activities. Interacts with SMARCA4/BRG1/BAF190A. Interacts (via C-terminus region) with SSRP1 and SUPT16H; the interaction is indicative of an interaction with the FACT complex.

Subcellular Location:
Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription initiation in developing embryos.

Post-translational modifications:
Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner. Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles.

Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain.

Database links:

Entrez Gene: 4656 Human

Entrez Gene: 17928 Mouse

Entrez Gene: 497618 Pig

Entrez Gene: 29148 Rat

Omim: 159980 Human

SwissProt: P15173 Human

SwissProt: P12979 Mouse

SwissProt: P49812 Pig

SwissProt: P20428 Rat

Unigene: 2830 Human

Unigene: 16528 Mouse

Unigene: 9465 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

MYOG是肌肉中运载氧的蛋白质,由153个氨基酸残基组成,一种小分子蛋白质,含有血红素,和血红蛋白同源,与氧的结合能力介于血红蛋白和细胞色素氧化酶之间,可帮助肌细胞将氧转运到线粒体。 肌细胞生成素在成肌分化过程中起着决定性的作用。在人体骨骼肌的胚胎发育过程中 ,肌细胞生成素伴随成肌过程而呈高水平表达。MYOG主要由肾脏代谢并排泄,当心肌或横纹肌有损伤时,肌红蛋白便释放入血中,血清中的肌红蛋白即可明显升高
   
   

Myogenin是一种肌特异性转录因子,可诱导组织培养中多种细胞类型的肌发生。它是由序列同源性、螺旋-环-螺旋(HLH)蛋白相关的大量蛋白质家族的成员。它对骨骼肌功能的发育至关重要。[ RefSeq,JUL 2008 ]

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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