FITC标记的抑癌蛋白EZH2抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的抑癌蛋白EZH2抗体
英文名称: Anti-KMT6/FITC
抗体货号: HZ-3521R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/10 10:55:00
详细资料:  实验方法技术资料
浏览人数:8
诚信指数:832点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
点此求购
在线QQ: 我是2043711056,请问我有什么可以帮到您呢?
生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
邮件:
公司展台:
在线QQ:
我是2043711056,请问我有什么可以帮到您呢?
扫一扫,关注我们

产品详细描述

 Rabbit Anti-KMT6/FITC Conjugated antibody

FITC标记的抑癌蛋白EZH2抗体

 

英文名称 Anti-KMT6/FITC
中文名称 FITC标记的抑癌蛋白EZH2抗体
别    名 Enhancer of zeste homolog 2; Enx1h; MGC9169; Enhancer of zeste 2; ENX-1; ENX 1; ENX1; EZH1; EZH2; EZH 2; EZH2_HUMAN; Histone-lysine N-methyltransferase EZH2; KMT6A; Lysine N-methyltransferase 6; Enhancer of zeste homolog 2 (Drosophila); Enhancer of zeste, Drosophila, homolog 2; KMT 6; KMT6; KMT6A; WVS2.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  神经生物学  生长因子和***  转录调节因子  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 82kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KMT6/EZH2 (285-332aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011].

Function:
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4.

Subunit:
Binds ATRX via the SET domain (Probable). Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit. Interacts with HDAC1 and HDAC2. Interacts with PRAME.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in many tissues. Overexpressed in numerous tumor types including carcinomas of the breast, colon, larynx, lymphoma and testis.

Post-translational modifications:
Phosphorylated by AKT1. Phosphorylation by AKT1 reduces methyltransferase activity. Phosphorylation at Thr-345 by CDK1 and CDK2 promotes maintenance of H3K27me3 levels at EZH2-target loci, thus leading to epigenetic gene silencing.
Sumoylated.

Similarity:
Belongs to the histone-lysine methyltransferase family. EZ subfamily.
Contains 1 CXC domain.
Contains 1 SET domain.

Database links:

Entrez Gene: 2146 Human

Entrez Gene: 14056 Mouse

Entrez Gene: 312299 Rat

Omim: 601573 Human

SwissProt: Q15910 Human

SwissProt: Q61188 Mouse

Unigene: 444082 Human

Unigene: 246688 Mouse

Unigene: 9027 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

    EZH2(enhancer of zeste homolog 2)是新识别的一种人类基因,是果蝇zeste基因增强子的人类同源基因,Polycomb group基因家族的重要成员之一。
    EZH2在多种肿瘤中高表达,具有促进细胞增殖,肿瘤细胞的扩散的恶性表型,EZH2在肿瘤中的作用成为研究热门。EZHZ在前列腺癌、乳腺癌、膀胧癌、肝细胞癌、大肠癌、胃癌中高表达;局限性前列腺癌、乳腺癌、膀胧癌高表达EZH2,则临床预后较差。因此EZH2可作为肿瘤标志物监测肿瘤的演变。随着PcG蛋白和TrxG蛋白复合物研究的深入,对细胞记忆机制的认识不断提高,而扰乱细胞的转录记忆系统可导致个体发育缺陷,使正常细胞丢失自身特性而癌变。
    EZH2通过基因沉默机制改变细胞的记忆系统并调控转录,促进前肿瘤恶性形成。EZH2在肿瘤发生发展中的作用仍远未阐明,特别是EZH2的下游基因仍不清楚,EZH2在肿瘤发生与发展的机制有待进一步研究
   
   

该基因编码多梳组(PCG)家族的成员。PCG家族成员形成多聚体蛋白复合物,参与维持基因在连续细胞世代中的转录抑制状态。该蛋白与胚胎外胚层发育蛋白、VAV1癌蛋白和X-连锁核蛋白相关。这种蛋白可能在造血和中枢神经系统中发挥作用。已经鉴定了多个交替编码的编码不同亚型的转录变体。[ RefSeq,FEB 2011 ]提供。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

查看FITC标记的抑癌蛋白EZH2抗体产品的用户还对以下产品感兴趣

暂无

ADVERTISEMENT

找不到您所需的产品,发布求购试试?

标题:*
描述:
姓名:*
Email:*
单位:*
电话:*
地址:*
邮编:
资料: 需要 不需要
报价: 需要 不需要