FITC标记的丝裂原活化蛋白激酶MKK6抗体
产品名称： FITC标记的丝裂原活化蛋白激酶MKK6抗体
英文名称： Anti-MEK6/FITC
产品编号： HZ-2911R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-MEK6/FITC Conjugated antibody
FITC标记的丝裂原活化蛋白激酶MKK6抗体
| 英文名称 | Anti-MEK6/FITC |
| 中文名称 | FITC标记的丝裂原活化蛋白激酶MKK6抗体 |
| 别 名 | MAP kinase kinase 6; MAPK/ERK kinase 6; MAPKK6; MAP2K6; MEK6; Mitogen Activated Protein Kinase Kinase 6; MKK 6; MKK6; PRKMK6; SAPKK3; Dual specificity mitogen activated protein kinase kinase 6; MKK 6; Dual specificity mitogen activated protein kinase kinase 6; EC 2.7.12.2; MP2K6_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 转录调节因子 激酶和磷酸酶 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MEK6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Mitogen activated protein kinase kinase 6 (MEK6 or MKK6) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MEK6, closely related to MEK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38, thus activating it, in response to inflammatory cytokines and environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this protein is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. Function: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38 exclusively. Subunit: Interacts with Yersinia yopJ. Subcellular Location: Tissue Specificity: Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas. Post-translational modifications: Weakly autophosphorylated. Phosphorylated by TAOK2. Acetylation of Ser-207 and Thr-211 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway. Similarity: Belongs to the enoyl-CoA hydratase/isomerase family. Database links: Entrez Gene: 5608 Human Entrez Gene: 26399 Mouse Entrez Gene: 114495 Rat Omim: 601254 Human SwissProt: P52564 Human SwissProt: P70236 Mouse Unigene: 463978 Human Unigene: 14487 Mouse Unigene: 17256 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
丝裂原活化蛋白激酶6（MEK6或MKK6）属于丝氨酸/苏氨酸蛋白激酶家族和MAPK激酶亚家族（MAP2K、MKK或MEKs）。MEK6，与MEK3密切相关，催化MAP激酶p38中苏氨酸和酪氨酸残基的伴随磷酸化，从而激活它，以响应炎性细胞因子和环境胁迫。
作为p38 MAP激酶介导的信号转导通路的重要组成部分，该蛋白参与了应激诱导的细胞周期阻滞、转录激活和凋亡等多种细胞过程。