FITC标记的PE标记小鼠抗人CD5单克隆抗体上海沪震实业有限公司

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产品名称: FITC标记的PE标记小鼠抗人CD5单克隆抗体
英文名称: Anti-human CD5-PE/FITC
抗体货号: HZ-30067M-PE-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: Flow-Cyt=1:50-200
更新时间: 2018/8/10 11:51:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-human CD5-PE/FITC Conjugated antibody

FITC标记的PE标记小鼠抗人CD5单克隆抗体

 

英文名称 Anti-human CD5-PE/FITC
中文名称 FITC标记的PE标记小鼠抗人CD5单克隆抗体
别    名 T-cell surface glycoprotein CD5; Lymphocyte antigen 1; Ly-1; Lyt-1; CD5; CD5 antigen; CD 5; CD5 molecule; CD5 antigen (p56 62); CD5_HUMAN; LEU 1; LEU1; Ly12; LyA; Lymphocyte Antigen CD5; Lymphocyte antigen T1/Leu 1; Lymphocyte antigen T1/Leu-1; Lymphocyte glycoprotein T1/Leu1; OTTHUMP00000236973; p56 62; T1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  干细胞  细胞表面分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 Flow-Cyt=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
性    状 Liquid
浓    度 2mg/1ml
免 疫 原  
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Function:
May act as a receptor in regulating T-cell proliferation.

Subunit:
Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Post-translational modifications:
Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.

Similarity:
Contains 3 SRCR domains.

Database links:
Entrez Gene: 921 Human
Omim: 153340 Human
SwissProt: P06127 Human
Unigene: 58685 Human


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

该基因编码调节补体介导的细胞裂解的细胞表面糖蛋白,参与淋巴细胞信号转导。这种蛋白质是补体膜攻击复合物的有力抑制剂,因此它在配合物的组装过程中结合补体C8和/或C9,从而抑制C9的多个复合体掺入复合物中,这是渗透压孔形成所必需的。该蛋白在T细胞活化过程中也起着信号转导通路的作用。该基因的突变导致CD59缺乏,这是一种导致溶血性贫血和血栓形成的疾病,并导致脑梗塞。多个交替剪接的转录变体,编码相同的蛋白质,已被鉴定为该基因。[ RefSeq,JUL 2008 ]

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