FITC标记的兔抗细胞角蛋白10单克隆抗体上海沪震实业有限公司

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产品名称: FITC标记的兔抗细胞角蛋白10单克隆抗体
英文名称: Anti-CK10/Cytokeratin 10/FITC
抗体货号: HZ-52052R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/10 11:56:00
详细资料:  实验方法技术资料
浏览人数:7
诚信指数:1084点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-CK10/Cytokeratin 10/FITC Conjugated antibody 

FITC标记的兔抗细胞角蛋白10单克隆抗体

 

英文名称 Anti-CK10/Cytokeratin 10/FITC
中文名称 FITC标记的兔抗细胞角蛋白10单克隆抗体
别    名 type I cytoskeletal 10; BCIE; BIE; CK 10; CK-10; ck10; Cytokeratin 10; Cytokeratin-10; Cytokeratin10; EHK; k10; K1C10_HUMAN; Keratin 10; Keratin; Keratin type i cytoskeletal 10; Keratin type I cytoskeletal 59 kDa; Keratin-10; Keratin10; kpp; Krt 10; KRT10; krt10; Keratin, type I cytoskeletal 10.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 信号转导  细胞骨架  细胞外基质  
抗体来源 Rabbit
克隆类型 Monoclonal
克 隆 号 1D8
交叉反应  
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 59kDa
性    状 Lyophilized or Liquid
浓    度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CK10/Cytokeratin 10
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. Cytokeratins 10 and 13 are present in the cytoskeletal region of a subset of squamous cell carcinomas. Cytokeratin 10 is a heterotetramer of two type I and two type II keratins, is generally associated with keratin 1, and is seen in all suprabasal cell layers including stratum corneum.

Subunit:
Belongs to the intermediate filament family.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Seen in all suprabasal cell layers including stratum corneum.

DISEASE:
Defects in KRT10 are a cause of bullous congenital ichthyosiform erythroderma (BCIE) [MIM:113800]; also known as epidermolytic hyperkeratosis (EHK) or bullous erythroderma ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.
Defects in KRT10 are a cause of ichthyosis annular epidermolytic (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.

Similarity:
Belongs to the intermediate filament family.

Database links:

Entrez Gene: 3858 Human

Entrez Gene: 16661 Mouse

Omim: 148080 Human

SwissProt: P13645 Human

SwissProt: P02535 Mouse

Unigene: 99936 Human

Unigene: 22662 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

细胞角蛋白包括一组不同的中间丝蛋白(IFP),它们在角化和非角化的上皮组织中表达成对。细胞角蛋白在分化和组织专一性和功能中起着至关重要的作用,以维持上皮细胞的整体结构完整性。细胞角蛋白已被发现是组织分化的有用标记,可直接应用于恶性肿瘤的表征。细胞角蛋白10和13在鳞状细胞癌的一个子集的骨架的区域。细胞角蛋白10是一种异源二I型和II型角蛋白2,通常与角蛋白1相关,而且是所有基底细胞层包括角质层过。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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