FITC标记的小鼠抗细胞色素P450 1A1单克隆抗体上海沪震实业有限公司

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产品名称: FITC标记的小鼠抗细胞色素P450 1A1单克隆抗体
英文名称: Anti-CYP1A1/FITC
抗体货号: HZ-51210M-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Mouse
抗原来源: Mouse
抗体来源: Mouse
适用物种: 
FITCconjugate:FITC
应用范围: 
更新时间: 2018/8/10 11:57:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Mouse Anti-CYP1A1/FITC Conjugated antibody

FITC标记的小鼠抗细胞色素P450 1A1单克隆抗体

 

英文名称 Anti-CYP1A1/FITC
中文名称 FITC标记的小鼠抗细胞色素P450 1A1单克隆抗体
别    名 Cytochrome p450 1A1; AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX; AHH; AHRR; Aryl hydrocarbon hydroxylase; CYP 1; CYP1A1; CYPIA1; Cytochrome P1-450; Flavoprotein-linked monooxygenase; Microsomal monooxygenase; P1 450; P450 C; P450 form 6; P450 P1; Xenobiotic monooxygenase.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  合成与降解  
抗体来源 Mouse
克隆类型 Monoclonal
克 隆 号 10G3
交叉反应 Human, 
产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 58kDa
性    状 Lyophilized or Liquid
浓    度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CYP1A1
亚    型 IgG1
纯化方法 affinity purified by Protein G
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The Cytochrome P450 (P450) superfamily of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several cofactors such as nicotinamide adenine dinucleotide phosphate (NADPH) and P450 reductase. There are over 200 known genes which encode P450s. Epoxygenases are those P450s which metabolize AA to epoxyeicosatrienoic acid (EETs) and omega hydroxylases are those P450s which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). As well as fatty acid metabolism, P450s also metabolize many drugs and toxins. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin.

Function:
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.

Subcellular Location:
Cytochrome P450 1A1: Cytoplasm.
Cytochrome P450MT2A: Endoplasmic reticulum membrane. Mitochondrion membrane. Microsome membrane. 
Cytochrome P450MT2B: Endoplasmic reticulum. Mitochondrion.

Tissue Specificity:
Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary.

Similarity:
Belongs to the cytochrome P450 family.

Database links:

Entrez Gene: 57491 Human

Entrez Gene: 11624 Mouse

Entrez Gene: 498999 Rat

Omim: 606517 Human

SwissProt: A9YTQ3 Human

SwissProt: Q3U1U7 Mouse

SwissProt: Q75NT5 Rat

Unigene: 50823 Human

Unigene: 290446 Mouse

Unigene: 145524 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

细胞色素P450(CYP450)酶超家族是三个酶系统代谢的脂肪酸,花生四烯酸(AA)对血管张力的调节器。细胞色素P450酶的单加氧酶,如需要几个辅因子烟酰胺腺嘌呤二核苷酸***酸(NADPH)和细胞色素P450还原酶。有超过两百个已知基因编码细胞色素P450。环氧化酶是P450代谢AA环氧二十碳三烯酸(EETs)和ω-羟化酶是P450产生19和20羟酸(19和20)。以及脂肪酸的代谢,细胞色素P450代谢的许多药物和毒素。细胞色素P450 3A4在肝脏和小肠中大量表达并诱导***类药物、糖皮质***和利福平。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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