FITC标记的磷酸化磷酯酶Cβ3抗体
产品名称： FITC标记的磷酸化磷酯酶Cβ3抗体
英文名称： Anti-Phospho-PLC beta3 (Ser537)/FITC
产品编号： HZ-3340R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Phospho-PLC beta3 (Ser537)/FITC Conjugated antibody
FITC标记的磷酸化磷酯酶Cβ3抗体
| 英文名称 | Anti-Phospho-PLC beta3 (Ser537)/FITC |
| 中文名称 | FITC标记的磷酸化磷酯酶Cβ3抗体 |
| 别 名 | PLC beta3 (Ser537); Phospholipase C beta 3; Phospholipase C beta 3 (phosphatidylinositol specific); PLC beta 3; PLCB3 antibody 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase beta 3; Phosphoinositide phospholipase C; PLCB3_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 免疫学 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 136kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human PLC beta3 around the phosphorylation site of Ser537 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Subunit: Interacts with SHANK2. Interacts with LPAR2. Subcellular Location: Membrane; Peripheral membrane protein. Similarity: Contains 1 C2 domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC Y-box domain. Database links: Entrez Gene: 5331 Human Entrez Gene: 18797 Mouse Entrez Gene: 29322 Rat Omim: 600230 Human SwissProt: Q01970 Human SwissProt: P51432 Mouse SwissProt: Q99JE6 Rat Unigene: 523761 Human Unigene: 591953 Human Unigene: 273204 Mouse Unigene: 16983 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码的蛋白与磷脂酰肌醇4,5-二磷酸催化的三磷酸肌醇和甘油二酯的形成。该反应使用钙离子作为辅助因子和受体介导的酪氨酸激酶激活的细胞内信号转导中起着重要的作用。例如，当激活Src，编码的蛋白导致Ras鸟嘌呤核苷酸交换因子RasGRP1转运到高尔基体，它可以激活RAS。同时，这种蛋白质已被证明是肝素结合生长因子1个主要底物（酸性成纤维细胞生长因子）激活酪氨酸激酶。两基因编码的不同亚型已发现这个基因。