FITC标记的磷酸化蛋白质酪氨酸激酶JAK-1抗体
产品名称： FITC标记的磷酸化蛋白质酪氨酸激酶JAK-1抗体
英文名称： Anti-Phospho-Jak1 (Tyr1034 + Tyr1035)/FITC
产品编号： HZ-3238R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 IF=1:50-200
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Rabbit Anti-Phospho-Jak1 (Tyr1034 + Tyr1035)/FITC Conjugated antibody
FITC标记的磷酸化蛋白质酪氨酸激酶JAK-1抗体
| 英文名称 | Anti-Phospho-Jak1 (Tyr1034 + Tyr1035)/FITC |
| 中文名称 | FITC标记的磷酸化蛋白质酪氨酸激酶JAK-1抗体 |
| 别 名 | JAK1 (phospho Y1034 + Y1035); p-JAK1 (phospho Y1034 + Y1035); JAK 1; JAK 1A; JAK 1B; JAK-1; JAK1; JAK1_HUMAN; JAK1A; JAK1B; Janus kinase 1 (a protein tyrosine kinase); Janus kinase 1; JTK3; Tyrosine protein kinase JAK 1; Tyrosine protein kinase JAK1; Tyrosine-protein kinase JAK1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 细胞生物 免疫学 染色质和核信号 信号转导 细胞凋亡 激酶和磷酸酶 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, |
| 产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 133kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human Jak1 around the phosphorylation site of Tyr1034 + Tyr1035 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Janus kinase 1 (JAK1) is a member of a new class of non-receptor protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. Function: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. Subunit: Interacts with FER. Interacts with IL31RA, IFNAR2, JAKMIP1 and SHB. Subcellular Location: Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated. Tissue Specificity: Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Contains 1 FERM domain. Contains 1 protein kinase domain. Contains 1 SH2 domain. Database links: Entrez Gene: 3716 Human Entrez Gene: 442952 Dog Entrez Gene: 16451 Mouse Entrez Gene: 84598 Rat Omim: 147795 Human SwissProt: P23458 Human SwissProt: P52332 Mouse Unigene: 207538 Human Unigene: 289657 Mouse Unigene: 90191 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
JAKUS激酶1（JAK1）是一类新的非受体蛋白酪氨酸激酶（PTK）的成员，其特征在于存在第二磷酸转移酶相关结构域，该结构域立即与PTK结构域的N端连接。二磷酸转移酶结构域具有蛋白激酶的所有特征，但其结构，PTK和苏氨酸/丝氨酸激酶家族成员明显不同。JAK1是一个大的，广泛表达的膜联蛋白。它与干扰素α/β和γ信号转导通路。在α-干扰素通路的JAK1和TYK2活性之间的相互依存关系，与JAK1和JAK2在γ-干扰素通路，可能反映干扰素recpeptor配合正确装配这些激酶的要求。这些激酶对细胞因子配体结合到各种已知的信号蛋白酪氨酸磷酸化和独特的家族的转录因子称为信号转导和转录激活因子或属性。