Rabbit Anti-C1orf124/FITC Conjugated antibody
|别 名||C1orf124; CA124_HUMAN; Chromosome 1 open reading frame 124; DDDL1880; dJ876B10.3; PRO4323; RP5-876B10.3; Zinc finger RAD18 domain-containing protein C1orf124.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 细胞生物 免疫学 神经生物学|
|交叉反应||Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||55kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human C1orf124|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf124 gene product has been provisionally designated C1orf124 pending further characterization.
Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.
Interacts with PCNA (when ubiquitinated). Interacts with RAD18. Interacts (via its SHP-box) with VCP/p97. Interacts with KCTD13 and POLD3.
Nucleus. Chromosome. Note=Localizes to sites of UV damage via the PIP-box. Recruited to stalled relication forks at sites of replication stress.
Belongs to the Spartan family.
Contains 1 SprT-like domain.
Contains 1 UBZ-type zinc finger.
Entrez Gene: 83932 Human
SwissProt: Q9H040 Human
Unigene: 554892 Human
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application
第1号染色体是最大的人类染色体，跨越2亿6000万个碱基对，占人类基因组的8%。在1号染色体上有大约3000个基因，并且考虑到大量的基因，也有大量的与染色体1相关的疾病。值得注意的是，罕见的衰老性疾病Hutchinson Gilford早老症与LMNA基因编码，lamin A.基因在缺陷时编码，LMNA基因产物可在细胞核中积聚并引起特征性核泡。迅速增强衰老的机制尚不清楚，是一个继续探索的话题。MutyH基因位于1号染色体上，是家族性腺瘤性息肉病的部分原因。Stutkle综合征、帕金森病、高雪氏病和Aukes综合征也与1号染色体有关。在1q中发现了一个断点，它破坏了DISC1基因并与精神分裂症联系在一起。染色体1的畸变在多种癌症中发现，包括头颈部癌、恶性黑色素瘤和多发性骨髓瘤。C1OF124基因产物已暂时指定为C1OF124，有待进一步鉴定。