FITC标记的磷酸化内收蛋白抗体上海沪震实业有限公司

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产品名称: FITC标记的磷酸化内收蛋白抗体
英文名称: Anti-phospho-alpha Adducin (Thr445)/FITC
抗体货号: HZ-12961R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/13 9:04:00
详细资料:  实验方法技术资料
浏览人数:8
诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
地址:
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邮编:
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电话:
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陈先生
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上海·中国-上海
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产品详细描述

 Rabbit Anti-phospho-alpha Adducin (Thr445)/FITC Conjugated antibody

FITC标记的***酸化内收蛋白抗体

 

英文名称 Anti-phospho-alpha Adducin (Thr445)/FITC
中文名称 FITC标记的***酸化内收蛋白抗体
别    名 Adducin (phospho T445); p-Adducin (phospho T445); ADD1; ADDA; Adducin 1 (alpha); Adducin 1; Alpha adducin; ADDA_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 肿瘤  细胞生物  信号转导  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 80kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human alpha Adducin around the phosphorylation site of Thr445
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha and beta adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha and gamma adducins are ubiquitously expressed. In contrast, beta adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca2+/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.

Function:
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.

Subunit:
Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit.

Subcellular Location:
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue Specificity:
Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.

Similarity:
Belongs to the aldolase class II family. Adducin subfamily.

Database links:

Entrez Gene: 118 Human
Entrez Gene: 11518 Mouse
Entrez Gene: 24170 Rat
Omim: 102680 Human
SwissProt: P35611 Human
SwissProt: Q9QYC0 Mouse
SwissProt: Q63028 Rat
Unigene: 183706 Human
Unigene: 289106 Mouse
Unigene: 5788 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

内收蛋白是由三个基因(α,β,γ)编码的细胞骨架蛋白家族。Adducin是一种由相关亚基组成的异源二聚蛋白,这些亚基由不同的基因产生,但具有相似的结构。α和β-内收蛋白包括蛋白酶抗性的N-末端区域和蛋白酶敏感的亲水性C-末端区域。α和γ-内收蛋白是普遍表达的。相反,β-内收蛋白在脑和造血组织中高表达。Adducin与Ca2+/钙调素具有高度亲和力,是蛋白激酶A和C的底物。选择性剪接导致多个变异体编码不同的异构体;然而,并非所有变异体都已完全描述。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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