FITC标记的磷酸化铁调节蛋白1抗体
产品名称： FITC标记的磷酸化铁调节蛋白1抗体
英文名称： Anti-phospho-Aconitase 1 (Ser138)/FITC
产品编号： HZ-12957R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-phospho-Aconitase 1 (Ser138)/FITC Conjugated antibody
FITC标记的磷酸化铁调节蛋白1抗体
| 英文名称 | Anti-phospho-Aconitase 1 (Ser138)/FITC |
| 中文名称 | FITC标记的磷酸化铁调节蛋白1抗体 |
| 别 名 | Aconitase 1 (phospho S138); p-Aconitase 1 (phospho S138); ACO 1; ACO1; ACOC_HUMAN; Aconitase 1 soluble; Aconitase; Aconitase1; Aconitate hydratase; ACONS; Citrate hydro lyase; Citrate hydro-lyase; Cytoplasmic aconitate hydratase; Ferritin repressor protein; IRE BP 1; IRE-BP 1; IREB 1; IREB1; IREBP; IREBP1; Iron regulatory protein 1; Iron responsive element binding protein 1; Iron-responsive element-binding protein 1; IRP 1; IRP1; OTTHUMP00000045233. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 心血管 细胞生物 信号转导 转录调节因子 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 98kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human Aconitase 1 around the phosphorylation site of Ser138 [AD(p-S)LQ] |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins; iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE–BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide. Function: Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. Subunit: Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210). Subcellular Location: Cytoplasm. Similarity: Belongs to the aconitase/IPM isomerase family. Database links: Entrez Gene: 48 Human Entrez Gene: 11428 Mouse Entrez Gene: 50655 Rat Omim: 100880 Human SwissProt: P21399 Human SwissProt: P28271 Mouse SwissProt: Q63270 Rat Unigene: 567229 Human Unigene: 331547 Mouse Unigene: 35934 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
铁代谢是维持哺乳动物体内平衡必不可少的。铁在哺乳动物细胞中的摄取和分布是一个高度调节的过程，由两种铁敏感蛋白监控：铁调节蛋白-1和-2（IRP-1和-2），也称为铁反应元件结合蛋白-1和-2（IRE-BP-1和-2）或乌头酶1和2。Irp-1和Irp-2是介导哺乳动物细胞铁摄取和贮存的重要的可溶性调节因子。它们通过与被称为铁反应元件（IRE）的茎环基序相关联，能够抑制翻译或增强mRNA的稳定性。IRP对应激介质、铁浓度和信号因子（包括一氧化氮、细胞因子和过氧化氢）作出反应。