FITC标记的1号染色体开放阅读框86抗体
产品名称: FITC标记的1号染色体开放阅读框86抗体
英文名称: Anti-C1orf86/FITC
产品编号: HZ-15079R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-C1orf86/FITC Conjugated antibody
FITC标记的1号染色体开放阅读框86抗体
英文名称 | Anti-C1orf86/FITC |
中文名称 | FITC标记的1号染色体开放阅读框86抗体 |
别 名 | C1orf86; CA086_HUMAN; Chromosome 1 open reading frame 86; FP7162; RP11-181G12.3; Uncharacterized protein C1orf86. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 细胞生物 免疫学 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 20kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human C1orf86 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1. Subunit: Component of the Fanconi anemia (FA) complex. Interacts with FANCA; interaction is direct. Interacts with REV1. Reported to bind monoubiquitinated REV1; however it binds better to non-ubiquitinated REV1 (PubMed:22266823). Subcellular Location: Nucleus. Chromosome. Note=Following DNA damage, recruited to DNA interstrand cross-links (ICLs) sites by binding to ubiquitin generated by RNF8. Similarity: Contains 1 UBZ-type zinc finger. Database links: Entrez Gene: 199990 Human Omim: 615183 Human SwissProt: Q6NZ36 Human Unigene: 107101 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
范可尼贫血(FA)复合物的组成部分,需要将FA复合物募集到DNA跨界交联(ICL)并促进ICL修复。在DNA损伤之后,识别并结合“Lys-63”连接的泛素,该泛素由RNF8在ICLs产生,并招募FA复合物的其他成分。通过与Rev1的相互作用促进跨损伤合成。