FITC标记的1号染色体开放阅读框85抗体上海沪震实业有限公司

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产品名称: FITC标记的1号染色体开放阅读框85抗体
英文名称: Anti-C1orf85/FITC
抗体货号: HZ-15078R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/13 9:17:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-C1orf85/FITC Conjugated antibody

FITC标记的1号染色体开放阅读框85抗体

 

英文名称 Anti-C1orf85/FITC
中文名称 FITC标记的1号染色体开放阅读框85抗体
别    名 C1orf85; Chromosome 1 open reading frame 85; Lysosomal protein NCU-G1; NCUG1_HUMAN; PSEC0030; UNQ2553/PRO6182.   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 40kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human C1orf85
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
C1orf85, also known as Lysosomal protein NCU-G1, is a 406 amino acid single-pass membrane protein that is highly glycosylated on its amino-terminal end. Transcription of the gene encoding C1orf85 is activated by TFEB, a transcription factor that specifically recognizes and binds E-box sequences. There are two isoforms of C1orf85 that are produced as a result of alternative splicing events. The C1orf85 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.

Subcellular Location:
Lysosome membrane; Single-pass type I membrane protein. 

Post-translational modifications:
Highly N-glycosylated (By similarity). 

Database links:
UniProtKB/Swiss-Prot: Q8WWB7.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

C1orf85,也称为溶酶体蛋白NCU-G1,是一种406个氨基酸的单程膜蛋白,在其氨基末端高度糖基化。编码C1orf85基因的转录被TFEB激活,TFEB是一种转录因子,可以特异性识别并结合E-box序列。有两种异构体的C1ORF 85,作为替代剪接事件的结果。C1orf85定位于人类染色体1,最大的人类染色体跨越约2.6亿个碱基对,占人类基因组的8%。在1号染色体上有大约3000个基因,并且考虑到大量的基因,也有大量的与染色体1相关的疾病。值得注意的是,罕见的衰老性疾病Hutchinson Gilford早老症与LMNA基因编码,lamin A.基因在缺陷时编码,LMNA基因产物可在细胞核中积聚并引起特征性核泡。迅速增强衰老的机制尚不清楚,是一个继续探索的话题。MutyH基因位于1号染色体上,是家族性腺瘤性息肉病的部分原因。Stutkle综合征、帕金森病、高雪氏病和Aukes综合征也与1号染色体有关。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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