FITC标记的1号染色体开放阅读框77抗体上海沪震实业有限公司

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产品名称: FITC标记的1号染色体开放阅读框77抗体
英文名称: Anti-C1orf77/FITC
抗体货号: HZ-
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/13 9:21:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-C1orf77/FITC Conjugated antibody

FITC标记的1号染色体开放阅读框77抗体

 

英文名称 Anti-C1orf77/FITC
中文名称 FITC标记的1号染色体开放阅读框77抗体
别    名 Chromatin target of PRMT1 protein; Chromosome 1 open reading frame 77; CHTOP; CHTOP_HUMAN; DKFZp547E1010; FOP; Friend of PRMT1 protein; MGC131924; MGC86949; OTTHUMP00000035122; OTTHUMP00000035123; Pp7704; RP1 178F15.2; Small arginine- and glycine-rich protein; Small protein rich in arginine and glycine; SRAG.   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human C1orf77
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
C1orf77, also known as Friend of PRMT1 protein, is a 248 amino acid protein that plays an essential role in the ligand-dependent activation of estrogen receptor target genes. C1orf77 is tightly associated with chromatin and is modified by both asymmetric and symmetric arginine methylation. Depletion of C1orf77 results in almost complete block of estradiol-induced promter occupancy by the estrogen receptor. Also, complete knockdown of C1orf77 mRNA in adult erythroid progenitors stongly induces fetal hemoglobin, suggesting that C1orf77 is a critical modulator of γ-globin gene expression. There are two isoforms of C1orf77 that are produced as a result of alternative splicing events. The gene encoding C1orf77 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1.

Function:
Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. 

Subunit:
Interacts with PRMT1 and PRMT5. Interacts with the 5FMC complex; the interaction is methylation-dependent. Interacts with FYTTD1, SET and PRC1 complex members CBX4, RNF2 and PHC2; the interactions are methylation-independent. Interacts with ZNF148 (By similarity). 

Subcellular Location:
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm (By similarity). Note=Mostly associated with facultative heterochromatin (By similarity). 

Tissue Specificity:
Expressed in an erythroid progenitor cell line derived from peripheral blood. 

Post-translational modifications:
Asymmetrically methylated by PRMT1. Symmetrically methylated by PRMT5 (By similarity). 

Database links:

Entrez Gene: 426357 Chicken

Entrez Gene: 738288 Chimpanzee

Entrez Gene: 616638 Cow

Entrez Gene: 480140 Dog

Entrez Gene: 101142690 Gorilla

Entrez Gene: 26097 Human

Entrez Gene: 66511 Mouse

Entrez Gene: 100153064 Pig

Entrez Gene: 361990 Rat

Entrez Gene: 715501 Rhesus monkey

Omim: 614206 Human

SwissProt: Q3SYW9 Cow

SwissProt: Q9Y3Y2 Human

SwissProt: Q9CY57 Mouse

SwissProt: Q498T2 Rat

Unigene: 611057 Human

Unigene: 154136 Mouse

Unigene: 15859 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

C1orf77,也被称为PRMT1蛋白之友,是一种248个氨基酸蛋白,在雌受体靶基因的配体依赖性激活中起重要作用。C1OF77与染色质紧密相关,并被不对称和对称的精氨酸甲基化修饰。C1OF77的缺失导致雌受体诱导的雌受体的完全占据。此外,成年红系祖先中C1orf77 mRNA的完全敲除强烈诱导胎儿血红蛋白,表明C1orf77是γ-珠蛋白基因表达的关键调节因子。作为替代剪接事件的结果,产生了两种C1OF77的异构体。编码C1orf77的基因定位于人类染色体1,最大的人类染色体跨越约2.6亿个碱基对,占人类基因组的8%。1号染色体上约有3000个基因,考虑到基因数量众多,也出现了大量与1号染色体相关的疾病。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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