FITC标记的1号染色体开放阅读框49抗体-抗体-抗体-生物在线
FITC标记的1号染色体开放阅读框49抗体

FITC标记的1号染色体开放阅读框49抗体

商家询价

产品名称: FITC标记的1号染色体开放阅读框49抗体

英文名称: Anti-C1orf49/FITC

产品编号: HZ-15067R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: ICC=1:50-200 IF=1:50-200

上海沪震实业有限公司
  • 联系人 : 鲍丽雯
  • 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
  • 邮编 : 200612
  • 所在区域 : 上海
  • 电话 : 139****0749
  • 传真 : 021-60345367
  • 邮箱 : www.shzbio.net

 Rabbit Anti-C1orf49/FITC Conjugated antibody

FITC标记的1号染色体开放阅读框49抗体

 

英文名称 Anti-C1orf49/FITC
中文名称 FITC标记的1号染色体开放阅读框49抗体
别    名 C1orf49; CA049_HUMAN; Chromosome 1 open reading frame 49; RP5-990P15.1; Testis expressed 35; Testis specific conserved gene 24kDa; TEX35; TSC24; Uncharacterized protein C1orf49.   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human C1orf49
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf49 gene product has been provisionally designated C1orf49 pending further characterization. There are four isoforms of C1orf49 that are produced as a result of alternative splicing events.

Tissue Specificity:
Testis-specific.

Database links:
UniProtKB/Swiss-Prot: Q5T0J7.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

第1号染色体是最大的人类染色体,跨越2亿6000万个碱基对,占人类基因组的8%。在1号染色体上有大约3000个基因,并且考虑到大量的基因,也有大量的与染色体1相关的疾病。值得注意的是,罕见的衰老性疾病Hutchinson Gilford早老症与LMNA基因编码,lamin A.基因在缺陷时编码,LMNA基因产物可在细胞核中积聚并引起特征性核泡。迅速增强衰老的机制尚不清楚,是一个继续探索的话题。MutyH基因位于1号染色体上,是家族性腺瘤性息肉病的部分原因。Stutkle综合征、帕金森病、高雪氏病和Aukes综合征也与1号染色体有关。在1q中发现了一个断点,它破坏了DISC1基因并与精神分裂症联系在一起。染色体1的畸变在多种癌症中发现,包括头颈部癌、恶性黑色素瘤和多发性骨髓瘤。C1OF49基因产物已暂时指定为C1OFF49,有待进一步鉴定。有四种异构体的C1ORF49,产生作为替代剪接事件的结果。