FITC标记的1号染色体开放阅读框187抗体
产品名称： FITC标记的1号染色体开放阅读框187抗体
英文名称： Anti-C1orf187/FITC
产品编号： HZ-15047R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
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Rabbit Anti-C1orf187/FITC Conjugated antibody
FITC标记的1号染色体开放阅读框187抗体
| 英文名称 | Anti-C1orf187/FITC |
| 中文名称 | FITC标记的1号染色体开放阅读框187抗体 |
| 别 名 | AGPA3119; C1orf187; Chromosome 1 open reading frame 187; Dorsal inhibitory axon guidance protein; Dorsal repulsive axon guidance protein; DRAXI_HUMAN; Draxin; FLJ34999; MGC117222; Neucrin; OTTHUMP00000002262; UNQ3119. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 发育生物学 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human C1orf187 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: C1orf187, also known as Draxin, Dorsal repulsive axon guidance protein and Neucrin, is a 349 amino acid secreted protein that is required of the development of the spinal cord and forebrain commissures. C1orf187 acts as a chemorepulsive guidance protein and directs commissural axons during development by repelling neurite outgrowth from the spinal cord. During development, C1orf187 modulates neural crest migration by reducing the polarization of these cells, leading to reduced velocity of migration and increased frequency of changing direction, leading to a net decrease in migrational distance. It acts as an antagonist of the Wnt signaling pathway by inhibiting the stabilization of cytosolic β-catenin via its interaction with LRP6. C1orf187 inhibits outgrowth from the olfactory bulb and likely contributes to the formation of the lateral olfactory tract. Function: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway (By similarity). Subunit: Interacts with LRP6 (By similarity). Subcellular Location: Secreted (Probable). Similarity: Belongs to the draxin family. Database links: UniProtKB/Swiss-Prot: Q8NBI3.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
C1orf187又称Draxin、背部排斥性轴突引导蛋白和神经肽，是脊髓和前脑连合发育所需的349个氨基酸分泌蛋白。C1orf187作为化学脉冲导向蛋白，在发育过程中通过排斥脊髓中突起的神经突起引导连合轴突。在发育过程中，C1orf187通过减少这些细胞的极化来调节神经嵴的迁移，导致迁移速度的降低和方向改变频率的增加，导致迁移距离的净减少。它通过与LRP6相互作用抑制胞浆β-连环素的稳定，从而作为Wnt信号通路的拮抗剂。C1ORF 187抑制嗅球的生长，可能有助于外侧嗅束的形成。