FITC标记的清道夫脱帽酶/热休克蛋白1抗体上海沪震实业有限公司

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产品名称: FITC标记的清道夫脱帽酶/热休克蛋白1抗体
英文名称: Anti-DCPS/FITC
抗体货号: HZ-12987R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/13 10:05:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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邮编:
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上海·中国-上海
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产品详细描述

 Rabbit Anti-DCPS/FITC Conjugated antibody

FITC标记的清道夫脱帽酶/热休克蛋白1抗体

 

英文名称 Anti-DCPS/FITC
中文名称 FITC标记的清道夫脱帽酶/热休克蛋白1抗体
别    名 1700001E16Rik; AA408441; DCPS; DCPS_HUMAN; DCS 1; DCS-1; DCS1; Decapping enzyme scavenger; heat shock-like protein 1; Hint 5; Hint related 7meGMP directed hydrolase; HINT-5; Hint-related 7meGMP-directed hydrolase; HINT5; Histidine triad protein member 5; homolog of C. elegans 7meGMP-directed hydrolase dcs-1; HSL1; HSPC015; m7GpppX diphosphatase; MGC124934; mRNA decapping enzyme; OTTMUSP00000042220; Scavenger mRNA decapping enzyme DcpS; Scavenger mRNA-decapping enzyme DcpS.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 38kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DCPS
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Eukaryotic cells primarily utilize exoribonucleases and decapping enzymes to degrade their mRNA. DcpS is a scavenger pyrophosphatase that hydrolyzes the residual cap structure following 3' to 5' decay of an mRNA. Following mRNA degradation DcpS releases N-7 methyl guanosine monophosphate and 5'-diphosphate terminated cap or mRNA products. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function. HIT proteins are homodimeric and contain two conserved 100-amino-acid HIT fold domains with independent active sites that are each sufficient to bind and hydrolyze cognate substrates.

Function:
Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides.

Subunit:
Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1. 

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Detected in liver, brain, kidney, testis and prostate.

Similarity:
Belongs to the HIT family.

Database links:
UniProtKB/Swiss-Prot: Q96C86.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

真核细胞主要利用外核糖核酸酶和解吸酶降解其mRNA。DCPS是一种清除剂焦***酸酶,在3’到5’mRNA的衰变后水解残冠结构。mRNA降解后,DCPS释放N-7甲基鸟苷酸单***酸和5’-二***酸封端的CAP或mRNA产物。在疾病预防控制中心组氨酸命中主题是去活性的关键定义打母题作为一种新的mRNA脱帽域,DcpS有明确的生物学功能的蛋白质家族的第一个成员打。打蛋白的二聚体和含有两个保守的100个氨基酸的打折域独立的活性位点,每个充分结合和水解的底物。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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