FITC标记的冷休克蛋白DBPA抗体
产品名称： FITC标记的冷休克蛋白DBPA抗体
英文名称： Anti-DBPA/FITC
产品编号： HZ-12985R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-DBPA/FITC Conjugated antibody
FITC标记的冷休克蛋白DBPA抗体
| 英文名称 | Anti-DBPA/FITC |
| 中文名称 | FITC标记的冷休克蛋白DBPA抗体 |
| 别 名 | Cold shock domain containing protein A; Cold shock domain-containing protein A; csdA; CSDA1; DBPA; DNA binding protein A; DNA-binding protein A; Single strand DNA binding protein NF GMB; Single-strand DNA-binding protein NF-GMB; ZO 1 associated nucleic acid binding protein; ZO1 associated nucleic acid binding protein; ZONAB; YBOX3_HUMAN; Y-box-binding protein 3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞周期蛋白 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DBPA/CSDA1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: CSDA is a 372 amino acid nuclear and cytoplasmic protein that is highly expressed in skeletal muscle and heart. Containing one CSD (cold-shock) domain, CSDA is thought to bind to GM-CSF promoter, full length mRNA and to short RNA sequences containing a specific consensus site. CSDA is suggested to have a role in translation repression and is found in a mRNP complex with MSY2. MSY2 belongs to the Y-box family of multifunctional proteins that regulate both transcription and translation. CSDA participates in promoting cell proliferation and expression of cyclin D1 and proliferating cell nuclear antigen (PCNA). CSDA is regarded to be an important component of the mechanisms that sense epithelial density and in regulating the switch between proliferation and differentiation through complex transcriptional networks. Function: Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Highly expressed in skeletal muscle and heart. Similarity: Contains 1 CSD (cold-shock) domain. Database links: Entrez Gene: 8531 Human Entrez Gene: 56449 Mouse Entrez Gene: 83807 Rat Omim: 603437 Human SwissProt: P16989 Human SwissProt: Q61478 Mouse SwissProt: Q68G78 Mouse SwissProt: Q8BPG0 Mouse SwissProt: Q9JKB3 Mouse SwissProt: Q3KRC7 Rat SwissProt: Q62764 Rat Unigene: 221889 Human Unigene: 299604 Mouse Unigene: 458000 Mouse Unigene: 3306 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
CSDA是一种在骨骼肌和心脏中高度表达的372氨基酸核和细胞质蛋白。CSDA包含一个CSD（冷休克）结构域，被认为与GM-CSF启动子、全长mRNA和包含特定共识位点的短RNA序列结合。CSDA被认为在翻译抑制中起作用，并在MyS2的MRNP复合物中发现。MyS2属于调节转录和翻译功能的多功能蛋白的Y-盒家族。CSDA参与促进细胞增殖和细胞周期蛋白D1和增殖细胞核抗原（PCNA）的表达。CSDA被认为是检测上皮密度和通过复杂转录网络调节细胞增殖和分化之间转换机制的重要组成部分。