FITC标记的补体C2b链多肽抗体上海沪震实业有限公司

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产品名称: FITC标记的补体C2b链多肽抗体
英文名称: Anti-C2b/FITC
抗体货号: HZ-15142R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: 
更新时间: 2018/9/13 10:18:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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200612
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陈先生
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上海·中国-上海
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产品详细描述

 Rabbit Anti-C2b/FITC Conjugated antibody

FITC标记的补体C2b链多肽抗体

 

英文名称 Anti-C2b/FITC
中文名称 FITC标记的补体C2b链多肽抗体
别    名 C2; C2 protein; C2b; C3/C5 convertase; CO 2; CO2; complement C2; Complement C2b fragment; Complement component 2; complement component C2; DKFZp779M0311; OTTHUMP00000062690; CO2_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 心血管  细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Complement C2b fragment
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009].

Function:
Component C2 which is part of the classical pathway ofthe complement system is cleaved by activated factor C1 into twofragments: C2b and C2a. C2a, a serine protease, then combines withcomplement factor 4b to generate the C3 or C5 convertase.

Subunit:
C2a interacts with Schistosoma haematobium TOR (viaN-terminal extracellular domain). This results in inhibition of theclassical and lectin pathway of complement activation, probably dueto interference with binding of C2a to C4b such that C3 convertasecannot be formed. This infers resistance to complement-mediatedcell lysis, allowing parasite survival and infection.

Subcellular Location:
Secreted.

DISEASE:
Defects in C2 are the cause of complement component 2deficiency (C2D) [MIM:217000]. A deficiency of the complementclassical pathway associated with the development of autoimmunedisorders, mainly systemic lupus erythematosus. Skin and jointmanifestations are common and renal disease is relatively rare.Patients with complement component 2 deficiency are also reportedto have recurrent or invasive infections.

Similarity:
Belongs to the peptidase S1 family. 
Contains 1 peptidase S1 domain. 
Contains 3 Sushi (CCP/SCR) domains. 
Contains 1 VWFA domain.

Database links:

Entrez Gene: 12263 Mouse

SwissProt: P21180 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application
   
   

成分C2是作为补体系统经典途径的一部分的血清糖蛋白。活化的C1将C2裂解成C2a和C2b。丝氨酸蛋白酶C2a然后与补体因子4b结合产生C3或C5转化酶。据报道,C2的缺乏与某些自身免疫性疾病有关,并且该基因中的SNP与年龄相关性黄斑变性的易感性改变有关。该基因定位在6号染色体短臂上MHC的III类区域内。选择性剪接导致多个转录变体编码不同的亚型。其他的转录体变体已经在出版物中进行了描述,但是它们的全长序列尚未确定。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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